虫草素通过调节结肠癌的肿瘤微环境增强PD-L1阻断的抗癌疗效。
Cordycepin enhances the Anticancer efficacy of PD-L1 blockade by modulating the tumor microenvironment of colon cancer.
作者信息
Feng Chen, Chen Rongzhang, Gao Xinran, Fang Weiwei, Wu Shaoxian, Chen Lujun, Zheng Xiao, Ji Xinyue, Yuan Maoling, Fu Yuanyuan, Ying Hanjie, Shen Tao, Zhu Dawei, Jiang Jingting
机构信息
Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, 213003, China; Jiangsu Engineering Research Center for Tumor Immunotherapy, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, 213003, China; Institute of Cell Therapy, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, 213003, China.
Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, 213003, China; Jiangsu Engineering Research Center for Tumor Immunotherapy, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, 213003, China; Institute of Cell Therapy, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, 213003, China; Department of Gynecology, Changzhou Traditional Chinese Medicine Hospital, Changzhou, Jiangsu, 213003, China.
出版信息
Eur J Pharmacol. 2024 Dec 15;985:177089. doi: 10.1016/j.ejphar.2024.177089. Epub 2024 Nov 1.
BACKGROUND
PD-L1 blockade has been found to be effective in treating multiple malignancies. Combined therapy is proposed to provide better therapeutic effects. Cordycepin, a prominent bioactive compound found in cordyceps, can inhibit the development of various cancers.
PURPOSE
This study aimed to determine the efficacy of combined anti-PD-L1 antibody and cordycepin in tumor treatment.
METHODS
A single-cell RNA sequencing was used to analyze the mechanism of combined treatment.
RESULTS
Combination therapy of anti-PD-L1 and cordycepin significantly inhibited tumor growth by regulating the T cell ratio and improving the function of CD8T cells. Furthermore, cordycepin promoted the reprogramming of type-II macrophages into type-I macrophages, a process confirmed through flow cytometry analysis of the underlying mechanism.
CONCLUSION
Our findings demonstrate that the combination of anti-PD-L1 and cordycepin effectively suppressed tumor growth by regulating the proportion of T cells and reprograming type-II macrophages.
背景
已发现程序性死亡受体配体1（PD-L1）阻断疗法在治疗多种恶性肿瘤方面有效。有人提出联合治疗可提供更好的治疗效果。虫草素是在冬虫夏草中发现的一种重要生物活性化合物，可抑制多种癌症的发展。
目的
本研究旨在确定抗PD-L1抗体与虫草素联合治疗在肿瘤治疗中的疗效。
方法
采用单细胞RNA测序分析联合治疗的机制。
结果
抗PD-L1与虫草素联合治疗通过调节T细胞比例和改善CD8T细胞功能，显著抑制肿瘤生长。此外，虫草素促进II型巨噬细胞重编程为I型巨噬细胞，这一过程通过对潜在机制的流式细胞术分析得到证实。
结论
我们的研究结果表明，抗PD-L1与虫草素联合使用可通过调节T细胞比例和重编程II型巨噬细胞有效抑制肿瘤生长。
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