Department of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center, 445 Great Circle Road, Nashville, TN 37228, USA.
Department of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center, 445 Great Circle Road, Nashville, TN 37228, USA.
Surg Pathol Clin. 2024 Dec;17(4):695-708. doi: 10.1016/j.path.2024.07.004. Epub 2024 Aug 26.
Hematologic malignancies are one of the more common neoplasms to occur in the sinonasal tract and include a wide range of entities, including mature and immature B cell and T cell neoplasms as well as plasma cell dyscrasias and histiocytic disorders. CD45 expression can be helpful in identifying many, but not all, hematopoietic neoplasms in the sinonasal tract, and more extensive immunophenotyping, including EBV in situ hybridization, as well as correlation with genetic results and clinical features may be required for diagnosis.
血液系统恶性肿瘤是发生于鼻窦的较常见肿瘤之一,包括广泛的实体瘤,包括成熟和不成熟 B 细胞和 T 细胞肿瘤以及浆细胞瘤和组织细胞疾病。CD45 表达有助于识别鼻窦内的许多但不是所有造血系统肿瘤,可能需要更广泛的免疫表型分析,包括 EBV 原位杂交,以及与遗传结果和临床特征的相关性,才能做出诊断。