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疟疾:过去、现在和未来。

Malaria: Past, present and future.

机构信息

Centre for Clinical Vaccinology and Tropical Medicine and Department of Biochemistry, University of Oxford, Oxford, UK.

Centre for Clinical Vaccinology and Tropical Medicine and Department of Biochemistry, University of Oxford, Oxford, UK.

出版信息

Clin Med (Lond). 2024 Nov;24(6):100258. doi: 10.1016/j.clinme.2024.100258. Epub 2024 Oct 25.

DOI:10.1016/j.clinme.2024.100258
PMID:39490741
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11605449/
Abstract

Malaria remains a major global health problem. Transmission occurs in 84 countries across five continents, with almost 250 million cases and over 600,000 deaths each year. Primary and secondary care clinicians in the UK need to be alert to the prospect of malaria presenting in returning travellers. They must be aware of the signs of severe malaria, the need for prompt diagnosis and treatment, and the importance of seeking specialist advice. With emerging resistance, climate change and the roll-out of the first malaria vaccines, the landscape of malaria is changing. Here we discuss the past, present and future of malaria.

摘要

疟疾仍然是一个主要的全球健康问题。该疾病在五大洲的 84 个国家传播,每年有近 2.5 亿例病例和超过 60 万人死亡。英国的初级和二级保健临床医生需要警惕疟疾在返回旅行者中出现的可能性。他们必须意识到严重疟疾的迹象,需要迅速诊断和治疗,以及寻求专家建议的重要性。随着新出现的耐药性、气候变化和第一批疟疾疫苗的推出,疟疾的形势正在发生变化。在这里,我们讨论疟疾的过去、现在和未来。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f87/11605449/49597f5e7992/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f87/11605449/49597f5e7992/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f87/11605449/49597f5e7992/gr1.jpg

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本文引用的文献

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2
Blood-stage malaria vaccine candidate RH5.1/Matrix-M in healthy Tanzanian adults and children; an open-label, non-randomised, first-in-human, single-centre, phase 1b trial.健康坦桑尼亚成年人及儿童中血期疟疾候选疫苗RH5.1/Matrix-M;一项开放标签、非随机、人体首例、单中心1b期试验。
Lancet Infect Dis. 2024 Oct;24(10):1105-1117. doi: 10.1016/S1473-3099(24)00312-8. Epub 2024 Jun 13.
3
Safety and efficacy of malaria vaccine candidate R21/Matrix-M in African children: a multicentre, double-blind, randomised, phase 3 trial.
前门处的传染病:聚焦基本要点。
Clin Med (Lond). 2024 Nov;24(6):100268. doi: 10.1016/j.clinme.2024.100268.
疟疾疫苗候选物 R21/Matrix-M 在非洲儿童中的安全性和有效性:一项多中心、双盲、随机、3 期临床试验。
Lancet. 2024 Feb 10;403(10426):533-544. doi: 10.1016/S0140-6736(23)02511-4. Epub 2024 Feb 1.
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Malaria.疟疾。
Lancet. 2023 Dec 16;402(10419):2328-2345. doi: 10.1016/S0140-6736(23)01249-7. Epub 2023 Nov 2.
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A brief history of malaria.疟疾简史
Presse Med. 2022 Sep;51(3):104130. doi: 10.1016/j.lpm.2022.104130. Epub 2022 Jun 3.
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British Society for Haematology guidelines for the laboratory diagnosis of malaria.英国血液学学会疟疾实验室诊断指南。
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Seasonal Malaria Vaccination with or without Seasonal Malaria Chemoprevention.季节性疟疾疫苗接种,无论是否进行季节性疟疾化学预防。
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