García-Marín J J, González J, Esteller A
Digestion. 1986;33(2):80-8. doi: 10.1159/000199278.
The effect of an intravenous infusion of sodium dehydrocholate on the maximum biliary transport (Tm) of bilirubin was studied in Wistar rats anesthetized with sodium pentobarbitone. Infusion of the synthetic bile salt at 0.24 mumol/min/100 g gave rise to a marked increase in bile flow (69%). The biliary output of taurocholate, phospholipid or cholesterol, compounds which from mixed micelles in bile, was not modified. Neither did the Tm of bilirubin undergo any significant changes, with drops in the bile concentration of the pigment. Our experimental results revealed that bile flow induced by dehydrocholate is not a determining factor of the Tm of bilirubin in the rat.
在戊巴比妥钠麻醉的Wistar大鼠中，研究了静脉输注去氢胆酸钠对胆红素最大胆汁转运量（Tm）的影响。以0.24 μmol/min/100 g的速度输注合成胆盐，可使胆汁流量显著增加（69%）。胆汁中形成混合微胶粒的牛磺胆酸盐、磷脂或胆固醇的排出量未发生改变。胆红素的Tm也未发生任何显著变化，同时胆汁中色素浓度下降。我们的实验结果表明，去氢胆酸盐诱导的胆汁流量不是大鼠胆红素Tm的决定性因素。
