猪模型中单相和双相脉冲电场消融波形的致心律失常性。
Arrhythmogenicity of monophasic and biphasic PFA waveforms in a porcine model.
作者信息
Kumru Hanife Tugba, Mattison Lars, Tarakji Khaldoun G, Verma Atul, Sigg Daniel C
机构信息
Medtronic, Minneapolis, Minnesota, USA.
McGill University, Montreal, Canada.
出版信息
J Cardiovasc Electrophysiol. 2024 Dec;35(12):2487-2490. doi: 10.1111/jce.16480. Epub 2024 Nov 3.
OBJECTIVE
The potential risk of inducing ventricular arrhythmias was explored by employing pulsed field ablation (PFA) through the administration of both monophasic and biphasic waveform deliveries.
METHODS
PFA was applied to specific locations in the right ventricle (RV, n = 5 sites) in swine (n = 2), utilizing identical settings with consistent amplitude, pulse width, and a number of pulses for both monophasic and biphasic waveforms. PFA deliveries were precisely timed in 10-ms intervals across the entire T wave.
RESULTS
Using monophasic waveforms, ventricular fibrillation (VF) was induced 7/7 times when PFA pulses were delivered during the T wave. Biphasic waveforms resulted in no ventricular arrhythmias when PFA was delivered across the entire duration of T wave.
CONCLUSIONS
Our findings indicate that VF can be consistently induced with monophasic pulse waveforms, but not with biphasic pulse waveforms in a porcine model.
目的
通过采用单相和双相波形传输的脉冲场消融（PFA）来探究诱发室性心律失常的潜在风险。
方法
在2头猪的右心室（RV，n = 5个部位）的特定位置应用PFA，对单相和双相波形使用相同的设置，包括一致的振幅、脉冲宽度和脉冲数量。PFA传输在整个T波期间以10毫秒的间隔精确计时。
结果
使用单相波形时，当在T波期间传输PFA脉冲时，7次中有7次诱发心室颤动（VF）。当在整个T波持续时间内进行PFA传输时，双相波形未导致室性心律失常。
结论
我们的研究结果表明，在猪模型中，单相脉冲波形可一致诱发VF，而双相脉冲波形则不会。
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