Department of Urology, Affiliated Zhongda Hospital of Southeast University, No. 87 Dingjiaqiao, Gulou District, Nanjing, 210009, Jiangsu, China.
Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Cell Mol Biol Lett. 2024 Nov 3;29(1):135. doi: 10.1186/s11658-024-00654-x.
MUC1 is a highly glycosylated transmembrane protein with a high molecular weight. It plays a role in lubricating and protecting mucosal epithelium, participates in epithelial cell renewal and differentiation, and regulates cell adhesion, signal transduction, and immune response. MUC1 is expressed in both normal and malignant epithelial cells, and plays an important role in the diagnosis, prognosis prediction and clinical monitoring of a variety of tumors and is expected to be a new therapeutic target. This article reviews the structural features, expression regulation mechanism, and research progress of MUC1 in the development of genitourinary cancers and its clinical applications.
黏蛋白 1 是一种高度糖基化的跨膜蛋白，具有高分子量。它在润滑和保护黏膜上皮中发挥作用，参与上皮细胞更新和分化，并调节细胞黏附、信号转导和免疫反应。黏蛋白 1 在正常和恶性上皮细胞中均有表达，在多种肿瘤的诊断、预后预测和临床监测中发挥重要作用，有望成为新的治疗靶点。本文综述了黏蛋白 1 在泌尿生殖系统癌症发生发展中的结构特征、表达调控机制及研究进展及其在临床上的应用。
