Division of Teaching and Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.
Department of Biology, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong, China.
Int J Mol Sci. 2021 Jun 18;22(12):6567. doi: 10.3390/ijms22126567.
The transmembrane glycoprotein mucin 1 (MUC1) is a mucin family member that has different functions in normal and cancer cells. Owing to its structural and biochemical properties, MUC1 can act as a lubricant, moisturizer, and physical barrier in normal cells. However, in cancer cells, MUC1 often undergoes aberrant glycosylation and overexpression. It is involved in cancer invasion, metastasis, angiogenesis, and apoptosis by virtue of its participation in intracellular signaling processes and the regulation of related biomolecules. This review introduces the biological structure and different roles of MUC1 in normal and cancer cells and the regulatory mechanisms governing these roles. It also evaluates current research progress and the clinical applications of MUC1 in cancer therapy based on its characteristics.
跨膜糖蛋白黏蛋白 1（MUC1）是黏蛋白家族的一员，在正常细胞和癌细胞中具有不同的功能。由于其结构和生化特性，MUC1 在正常细胞中可以作为润滑剂、保湿剂和物理屏障。然而，在癌细胞中，MUC1 经常经历异常的糖基化和过度表达。它通过参与细胞内信号过程和相关生物分子的调节，参与癌症的侵袭、转移、血管生成和凋亡。本综述介绍了 MUC1 在正常细胞和癌细胞中的生物学结构和不同作用，以及调控这些作用的机制。还基于 MUC1 的特性评估了其在癌症治疗中的当前研究进展和临床应用。
