Poncin E, Silvain C, Touchard G, Barbier J, Beauchant M
Gastroenterology. 1986 Apr;90(4):1051-3. doi: 10.1016/0016-5085(86)90887-5.
The case history of a women with jaundice and laboratory evidence of chronic active hepatitis and cirrhosis is reported. The patient had taken papaverine for 6 yr for cerebral arterial disease. Jaundice improved after the drug was discontinued but reappeared when papaverine therapy was reintroduced. Antinuclear antibody and smooth muscle antibody were present. Clinical manifestations disappeared and laboratory results again returned to normal upon withdrawal of papaverine. This case suggests that papaverine should be added to the list of drugs known to produce chronic active hepatitis and cirrhosis.
报告了一名患有黄疸且有慢性活动性肝炎和肝硬化实验室证据的女性病例史。该患者因脑动脉疾病服用罂粟碱6年。停药后黄疸改善，但重新引入罂粟碱治疗时黄疸再次出现。存在抗核抗体和平滑肌抗体。停用罂粟碱后，临床表现消失，实验室检查结果再次恢复正常。该病例提示，罂粟碱应被列入已知可导致慢性活动性肝炎和肝硬化的药物名单中。
