罂粟碱与肝毒性。

Papaverine and hepatotoxicity.

作者信息

Pathy M S, Reynolds A J

出版信息

Postgrad Med J. 1980 Jul;56(657):488-90. doi: 10.1136/pgmj.56.657.488.

DOI:10.1136/pgmj.56.657.488

PMID:7003573

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2425822/

Abstract

Six of 14 patients receiving a sustained release papaverine preparation developed abnormal liver function tests. One patient had jaundice and another abnormal liver histology on a biopsy specimen. This is only the third report of impaired liver function following the administration of papaverine--a drug which has been used in clinical medicine for over 100 years.

摘要

14名接受缓释罂粟碱制剂治疗的患者中有6名肝功能检查出现异常。一名患者出现黄疸，另一名患者活检标本的肝脏组织学异常。这只是服用罂粟碱后肝功能受损的第三例报告——罂粟碱是一种已在临床医学中使用了100多年的药物。