间充质干细胞衍生的细胞外囊泡用于治疗儿童和成人肠道移植中的急性排斥反应。
Mesenchymal stem cell-derived extracellular vesicles for the treatment of acute rejection in pediatric and adult bowel transplant.
作者信息
Levitte Steven, Zhang Ke-You, Guevara-Tique Alix A, Ganguly Abantika, Dulken Ben W, Nilkant Riya, Rigmaiden Martina, Kumari Radhika, Khlifi Khalil, Thakor Avnesh S, Bonham Clark A
机构信息
Interventional Radiology Innovation at Stanford (IRIS), 3155 Porter Drive, Palo Alto, CA, 94304; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University, Palo Alto, CA 94304, USA.
Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University, Palo Alto, CA 94304, USA.
出版信息
Am J Transplant. 2023 Oct 27. doi: 10.1016/j.ajt.2023.10.019.
Mesenchymal stem cells are under investigation as a novel therapy to treat solid organ transplant rejection. However, significant hurdles have limited their use in humans. Mesenchymal stem cell-derived extracellular vesicles address many of these shortcomings but have not been investigated clinically. Here we report our experience treating two patients with graft rejection and inflammation following bowel transplant using mesenchymal stem cell-derived extracellular vesicles.
间充质干细胞正作为一种治疗实体器官移植排斥反应的新型疗法进行研究。然而，重大障碍限制了它们在人类中的应用。间充质干细胞衍生的细胞外囊泡解决了许多这些缺点，但尚未进行临床研究。在此，我们报告了使用间充质干细胞衍生的细胞外囊泡治疗两名肠移植后出现移植物排斥和炎症患者的经验。
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