Cai Jiaxin, Wu Junyong, Wang Jiemin, Li Yongjiang, Hu Xiongbin, Luo Shifu, Xiang Daxiong
1Department of Pharmacy, The Second Xiangya Hospital, Central South University, Furong District, Changsha, Hunan China.
Hunan Provincial Engineering Research Centre of Translational Medicine and Innovative Drug, Changsha, Hunan China.
Cell Biosci. 2020 May 24;10:69. doi: 10.1186/s13578-020-00427-x. eCollection 2020.
Mesenchymal stem cells (MSCs) were known to have excellent properties in cell therapy. However, the risk of immune rejection associated with cell transplant therapy hampers its use. Extracellular vesicles secreted by MSCs derived from different sources that contain therapeutic molecules such as RNA and proteins, which is a novel strategy for cell-free therapy. Recently, researches show EVs from MSCs (MSC-EVs) of different sources have special functions and effects on different diseases. Here, we collected these researches and compared them to each other. In addition, their potential and possible application in clinical treatment are described.
间充质干细胞（MSCs）在细胞治疗中具有优异的特性。然而，与细胞移植治疗相关的免疫排斥风险阻碍了其应用。来自不同来源的间充质干细胞分泌的细胞外囊泡含有RNA和蛋白质等治疗分子，这是一种无细胞治疗的新策略。最近的研究表明，不同来源的间充质干细胞来源的细胞外囊泡（MSC-EVs）对不同疾病具有特殊的功能和作用。在此，我们收集了这些研究并进行相互比较。此外，还描述了它们在临床治疗中的潜力和可能的应用。
