实验性破伤风毒素中毒大鼠的颈动脉化学感受器反射

Carotid chemoreceptor reflex in rats during experimental tetanus toxicity.

作者信息

Sofola O A, Gbenebiche S O, Adegoke F

出版信息

Gen Pharmacol. 1986;17(1):113-6. doi: 10.1016/0306-3623(86)90022-4.

Abstract

The effects of stimulation of carotid body chemoreceptors on blood pressure, heart rate and ventilation were compared in normal rats and rats with local or generalised tetanus toxicity induced by injection of the toxin. Carotid chemoreceptor stimulation in an increase in blood pressure and a decrease in heart rate in both control and tetanus rats. However, while chemoreceptor stimulation resulted in increases in ventilation of 115% and 123% in normal rats and rats with local tetanus respectively, the increase in rats with generalised tetanus was only 29%. The experiments indicate that normal rats and rats with tetanus toxicity exhibit identical pressor and heart rate responses to stimulation of carotid chemoreceptors whereas the ventilatory response is attenuated in the tetanus rats.

摘要

在正常大鼠以及通过注射毒素诱导产生局部或全身性破伤风毒性的大鼠中，比较了刺激颈动脉体化学感受器对血压、心率和通气的影响。在对照大鼠和破伤风大鼠中，刺激颈动脉化学感受器均导致血压升高和心率降低。然而，虽然化学感受器刺激在正常大鼠和局部破伤风大鼠中分别使通气增加了115%和123%，但在全身性破伤风大鼠中仅增加了29%。实验表明，正常大鼠和患有破伤风毒性的大鼠对刺激颈动脉化学感受器表现出相同的升压和心率反应，而破伤风大鼠的通气反应减弱。