Wang-Schweig Meme, Zimmer Sara, Kirshenbaum Ari, Mudd Lydia, Slade Mackenzie
Cannabis Public Policy Consulting (CPPC), Sudbury, MA, USA.
J Psychoactive Drugs. 2024 Nov 3:1-11. doi: 10.1080/02791072.2024.2420042.
International consensus has emerged, which proposes that the measurement and standardization of the quantity of THC potency, or dose (mgTHC), is a requisite for identifying consistent relationships between patterns of cannabis use and the risk for negative health outcomes, especially critical given the increasing number of U.S. states and European countries considering legalizing cannabis for recreational use. Despite the lack of measurement approaches that provide accurate, real-time data on THC dosage, the number of states that have implemented legal adult use cannabis markets has coincided with the use of regulatory seed-to-sale or track-and-trace systems. Seed-to-sale tracking systems are designed to track the amount of cannabis cultivated, and typically leverage biochemical testing contractors to label the THC potencies and amounts on a diverse array of cannabis products. We propose leveraging seed-to-sale tracking systems to facilitate a more objective measure of THC potency. In the current review, we will: 1) summarize the complexities of accurately measuring the multidimensional aspects of cannabis use patterns; 2) review recent advancements in quantifying THC and the importance of standardizing THC dose in measuring cannabis use; and 3) discuss the potential value of future research efforts examining how state-level seed-to-sale tracking data can inform the standard THC dose.
国际上已达成共识，即对四氢大麻酚（THC）效力或剂量（毫克THC）的测量及标准化，是确定大麻使用模式与负面健康后果风险之间一致关系的必要条件，鉴于越来越多的美国州和欧洲国家考虑将大麻用于娱乐用途合法化，这一点尤为关键。尽管缺乏能提供关于THC剂量准确实时数据的测量方法，但已实施合法成人用大麻市场的州数量与使用监管性的从种子到销售或追踪溯源系统相吻合。从种子到销售的追踪系统旨在追踪种植的大麻数量，通常利用生化检测承包商为各类大麻产品标注THC效力和含量。我们建议利用从种子到销售的追踪系统来促进对THC效力进行更客观的测量。在当前综述中，我们将：1）总结准确测量大麻使用模式多维度方面的复杂性；2）回顾量化THC的最新进展以及在测量大麻使用中标准化THC剂量的重要性；3）讨论未来研究工作的潜在价值，这些研究探讨州级从种子到销售的追踪数据如何为标准THC剂量提供信息。
