Antipenskaia L V, Iliukhina T A, Atramentova L A
Genetika. 1986 Jan;22(1):158-63.
Examination of randomly selected pregnant women of the Kharkov city showed that the structure of marriage had undergone considerable changes during two successive generations. The number of endogamous marriages decreased, the percentage of marriages between persons of different nationalities being increased, which adequately reflects social-demographic processes taking place currently in all human populations. Judging by the data obtained, these changes in percentage of exogamous marriages do not considerably influence the probability of pregnancy failure which can be accounted for disturbed foeto-maternal immunological interrelations. No correlations between immunological indices and the degree of heterozygosity in women and the structure of marriages was demonstrated. The percentage of married couples with tainted heredity (spontaneous abortions, still-birth) was considerably higher among women with habitual pregnancy failure, which may testify to a certain role of hereditary predisposition to immune failure.
对哈尔科夫市随机抽取的孕妇进行检查发现,在连续两代人的时间里,婚姻结构发生了相当大的变化。族内通婚的数量减少,不同民族之间通婚的比例增加,这充分反映了目前在所有人类群体中发生的社会人口学进程。从所获得的数据来看,异族通婚比例的这些变化对妊娠失败的概率没有显著影响,妊娠失败可能是由于母婴免疫相互关系紊乱所致。未发现免疫指标与女性杂合度程度及婚姻结构之间存在相关性。在习惯性妊娠失败的女性中,有遗传缺陷(自然流产、死产)的已婚夫妇比例明显更高,这可能证明遗传易感性对免疫失败有一定作用。