Kucher A N, Dubrova Iu E, Kurbatova O L, Altukhov Iu P
Genetika. 1987 Sep;23(9):1671-83.
Hereditary variation of 5 immunological systems coded by 8 loci was compared in 148 couples and 100 women with repeated spontaneous abortions in anamnesis (experimental group) and 141 couples and 100 women with normal fertility (control group). Marked differences in distributions of genotypes and frequencies of 3 systems (MNSs, Rhesus, Duffy) and frequency of AB0-incompatible couples were found between control and experimental groups. An average value of observed heterozygosity in experimental group was lower, as compared to the expected value. Possible influence of immunological factors on recurrent fetal wastage is discussed.
对148对夫妇以及100名有反复自然流产病史的女性（实验组）和141对夫妇以及100名生育能力正常的女性（对照组）编码于8个基因座的5个免疫系统的遗传变异进行了比较。在对照组和实验组之间发现了3个系统（MNSs、恒河猴、达菲）的基因型分布和频率以及AB0血型不相容夫妇频率存在显著差异。与预期值相比，实验组观察到的杂合度平均值较低。讨论了免疫因素对反复胎儿丢失的可能影响。
