The Second Clinical Medical School, Lanzhou University, Lanzhou, People's Republic of China.
Laboratory Medicine Center Gansu Provincial Natural Science, Lanzhou University Second Hospital, People's Republic of China.
Gene. 2025 Jan 30;935:149074. doi: 10.1016/j.gene.2024.149074. Epub 2024 Nov 2.
Genomic instability is regardedas a hallmark of cancer cells. It can be presented in many ways, among which chromosome instability has received attention. Ultrafine anaphase bridges are a typeof chromatin bridges, the untimely resolution of which can also lead to chromosome instability. PICH can play a role in maintaining chromosome stability by regulating chromosome morphologyand resolving ultrafine anaphase bridges. Recently, PICH has been found to be overexpressed in various cancers. Overexpression of PICH is related to the proliferation of tumors and poor prognosis. In this article, we consider that PICH can maintain genomic stability by regulating appropriate chromosome structure, ensuring proper chromosome segregation, and facilitating replication fork reversal. We summarize how PICH regulates chromosome stability, how PICH resolves Ultrafine anaphase bridges with other proteins, and how PICH promotes tumor progression.
基因组不稳定性被认为是癌细胞的一个标志。它可以以多种方式表现出来，其中染色体不稳定性受到了关注。超微后期桥是一种染色质桥，其过早的解决也会导致染色体不稳定性。PICH 通过调节染色体形态和解决超微后期桥来发挥维持染色体稳定性的作用。最近，发现 PICH 在各种癌症中过度表达。PICH 的过度表达与肿瘤的增殖和不良预后有关。在本文中，我们认为 PICH 可以通过调节适当的染色体结构来维持基因组稳定性，确保适当的染色体分离，并促进复制叉反转。我们总结了 PICH 如何调节染色体稳定性，PICH 如何与其他蛋白质一起解决超微后期桥，以及 PICH 如何促进肿瘤进展。
