Diaz G, Carta S, Orzalesi N
Graefes Arch Clin Exp Ophthalmol. 1986;224(2):147-51. doi: 10.1007/BF02141488.
Coated pits (CPs) and coated vesicles (CVs) are distributed nonrandomly along the surface of the connective tissue cells of the rabbit trabecular meshwork. Morphometric and statistical analyses of the distances between consecutive structures reveal a tendency to cluster, which is apparently higher among CVs than among CPs. The spatial relationship between CVs and CPs is also demonstrated by the analysis of their association (presence/absence) in each cell. The data suggest the hypothesis that each cluster is formed by structures in the same stage of maturation. In addition to the recent demonstration of the clustering of CPs in transformed cells in vitro (Pfeiffer et al. 1980), our findings indicate that: (a) clustering is characteristic of both CVs and CPs; (b) it also occurs in normal tissue cells; (c) it represents a further peculiarity, which confirms the specific nature of receptor-mediated endocytosis; (d) it reflects, at a higher level, the clustering of the receptor molecules, which are responsible for the high selectivity of the endocytic process.
包被小窝（CPs）和包被小泡（CVs）沿兔小梁网结缔组织细胞表面呈非随机分布。对连续结构之间距离的形态计量学和统计分析显示出聚集倾向，CVs中的这种倾向明显高于CPs。通过分析它们在每个细胞中的关联（存在/不存在），也证明了CVs和CPs之间的空间关系。数据提示了这样一个假说，即每个簇由处于相同成熟阶段的结构形成。除了最近在体外转化细胞中证明CPs的聚集（Pfeiffer等人，1980）外，我们的研究结果表明：（a）聚集是CVs和CPs的特征；（b）它也发生在正常组织细胞中；（c）它代表了另一个独特之处，证实了受体介导的内吞作用的特异性；（d）它在更高水平上反映了受体分子的聚集，这些受体分子负责内吞过程的高选择性。
