基于化学稳定的镍（II）金属有机框架的用于血清和尿液中生物标志物检测的双功能发光传感器。
A bifunctional luminescence sensor for biomarkers detection in serum and urine based on chemorobust Nickel(II) metal-organic framework.
作者信息
Lei Nana, Li Wencui, Zhao Dongsheng, Li Wenqian, Liu Xin, Liu Liying, Yin Jingrui, Muddassir Mohd, Wen Rongmei, Fan Liming
机构信息
School of Chemistry and Chemical Engineering, North University of China, Taiyuan 030051, PR China.
Department of Chemistry, College of Sciences, King Saud University, Riyadh 11451, Saudi Arabia.
出版信息
Spectrochim Acta A Mol Biomol Spectrosc. 2023 Oct 28;306:123585. doi: 10.1016/j.saa.2023.123585.
The rapid detection of biomarkers in bodily fluids is vital for clinical diagnosis and regular disease monitoring. In this work, a mixed-ligand strategy was employed to successfully construct a nickel(II) metal-organic framework ([Ni(HTPTC)(bib)(HO)], NiMOF). Outstanding thermal and chemical stabilities coupled with the favorable luminescent performances endow NiMOF significant potential as an ideal bifunctional luminescence sensor with high selectivity and sensitivity, exceptional anti-interferences and recyclable performances, as well as low LODs for detecting 3-NT biomarker through "turn-off" luminescence quenching effects and HA biomarker through "turn-on" luminescence enhancement effects. Furthermore, such developed sensor was employed to quantify 3-NT biomarker in serum samples and HA biomarker in urine samples withsatisfactory results. In addition, the possible sensing mechanisms of NiMOF towards HA and 3-NT were also proposed. This work indicates the great potentials of MOFs-based biomarkers chemosensors.
生物标志物在体液中的快速检测对于临床诊断和疾病常规监测至关重要。在这项工作中，采用混合配体策略成功构建了一种镍（II）金属有机框架（[Ni(HTPTC)(bib)(HO)]，NiMOF）。出色的热稳定性和化学稳定性以及良好的发光性能使NiMOF作为一种理想的双功能发光传感器具有巨大潜力，该传感器具有高选择性和灵敏度、出色的抗干扰和可回收性能，以及通过“关断”发光猝灭效应检测3-NT生物标志物和通过“开启”发光增强效应检测HA生物标志物的低检测限。此外，这种开发的传感器用于定量血清样品中的3-NT生物标志物和尿液样品中的HA生物标志物，结果令人满意。此外，还提出了NiMOF对HA和3-NT的可能传感机制。这项工作表明了基于金属有机框架的生物标志物化学传感器的巨大潜力。
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