College of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059, P. R. China.
Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059, P. R. China.
Inorg Chem. 2023 Jul 17;62(28):11168-11178. doi: 10.1021/acs.inorgchem.3c01290. Epub 2023 Jul 6.
A new Eu-centered metal-organic framework, [(CH)NH][Eu(cdip)(HO)] (compound ), was fabricated by the reaction of Eu(NO)·6HO and a high-symmetry ligand, 5,5'-carbonyldiisophthalic acid (Hcdip). Interestingly, compound exhibits extraordinary stability, including air, thermal, and chemical stabilities, in an aqueous solution with a broad pH range of 1-14, which is rarely seen in the field of metal-organic framework materials. Notably, compound is proved to be an exceptional prospective luminescent sensor for recognizing 1-hydroxypyrene and uric acid both in DMF/HO solution and human urine with a fast response (1-HP: 10 s; UA: 80 s), high quenching efficiency (7.01 × 10 M for 1-HP and 5.46 × 10 M for UA in DMF/HO solution; 2.10 × 10 M for 1-HP and 3.43 × 10 M for UA in human urine), low limit of detection (1.61 μM for 1-HP and 0.54 μM for UA in DMF/HO solution; 0.71 μM for 1-HP and 0.58 μM for UA in human urine), and remarkable anti-interference ability based on luminescence-quenching effects observable by the naked eye. This work provides a new strategy for the exploration of potential luminescent sensors based on Ln-MOFs for 1-HP, UA, or other biomarkers in biomedical and biological fields.
一种新的以 Eu 为中心的金属有机骨架[(CH)NH][Eu(cdip)(HO)]（化合物），是由 Eu(NO)·6HO 和一个高对称配体 5,5'-羰基二异酞酸（Hcdip）反应得到的。有趣的是，化合物在 pH 值为 1-14 的宽范围内的水溶液中具有非凡的稳定性，包括空气、热和化学稳定性，这在金属有机骨架材料领域是很少见的。值得注意的是，化合物被证明是一种出色的潜在发光传感器，可用于识别 DMF/HO 溶液和人尿中的 1-羟基芘和尿酸，具有快速响应（1-HP：10 s；UA：80 s）、高猝灭效率（在 DMF/HO 溶液中，对 1-HP 的 7.01×10 M 和对 UA 的 5.46×10 M；在人尿中，对 1-HP 的 2.10×10 M 和对 UA 的 3.43×10 M）、低检测限（在 DMF/HO 溶液中，对 1-HP 的 1.61 μM 和对 UA 的 0.54 μM；在人尿中，对 1-HP 的 0.71 μM 和对 UA 的 0.58 μM）和基于肉眼可见的发光猝灭效应的出色抗干扰能力。这项工作为基于 Ln-MOFs 的潜在发光传感器的探索提供了一种新策略，用于生物医学和生物学领域中的 1-HP、UA 或其他生物标志物。
