Li Zizheng, Qiao Ou, Wang Yuru, Li Ning, Gong Yanhua
Institute of Disaster and Emergency Medicine, Medical School, Tianjin University, No. 92 Weijin Road, Nankai District, Tianjin, 300072, China; Tianjin Key Laboratory of Disaster Medicine Technology, Tianjin, 300072, China.
Institute of Disaster and Emergency Medicine, Medical School, Tianjin University, No. 92 Weijin Road, Nankai District, Tianjin, 300072, China; Tianjin Key Laboratory of Disaster Medicine Technology, Tianjin, 300072, China; Thinking Biomed (Beijing) Co., Ltd, Beijing Economic and Technological Development Zone, Beijing, 100176, China.
Trends Pharmacol Sci. 2023 Oct 26. doi: 10.1016/j.tips.2023.10.001.
Despite advances in medical treatments for severe trauma, it remains a critical condition associated with high mortality. During trauma, the release of endogenous damage-associated molecular patterns (DAMPs) can induce immune dysfunction, leading to sepsis or multiple organ dysfunction syndrome (MODS). Vaccines based on specific pathogen antigens and pathogen-associated molecular patterns (PAMPs) contribute largely to the prevention of communicable diseases through the induction of adaptive immune responses. Vaccines developed based on autologous molecules may also promote recovery from non-communicable diseases (NCDs) by eliciting appropriate immune responses, as recent clinical trials indicate. Developing new vaccines targeting DAMPs may be an effective pre-protective measure for trauma management. We describe the role of DAMPs in post-traumatic immune dysfunction and discuss the potential of harnessing them for trauma vaccine development as well as the risks and challenges.
尽管严重创伤的医学治疗取得了进展，但它仍然是一种与高死亡率相关的危急病症。在创伤过程中，内源性损伤相关分子模式（DAMPs）的释放可诱导免疫功能障碍，导致脓毒症或多器官功能障碍综合征（MODS）。基于特定病原体抗原和病原体相关分子模式（PAMPs）的疫苗通过诱导适应性免疫反应，在很大程度上有助于预防传染病。正如最近的临床试验所示，基于自体分子开发的疫苗也可能通过引发适当的免疫反应促进非传染性疾病（NCDs）的康复。开发针对DAMPs的新型疫苗可能是创伤管理的一种有效的预先保护措施。我们描述了DAMPs在创伤后免疫功能障碍中的作用，并讨论了将其用于创伤疫苗开发的潜力以及风险和挑战。
