Tade Tadić, Clinical Department of Diagnostic and Interventional Radiology, University Hospital Split, Šoltanska 2, 21000 Split, Croatia,
Croat Med J. 2024 Oct 31;65(5):440-449. doi: 10.3325/cmj.2024.65.440.
We systematically reviewed the current research literature to 1) investigate whether there was a difference in bone mineral density (BMD) between chronic obstructive pulmonary disease (COPD) patients and non-COPD controls, 2) determine the influence of severity and subtype of COPD on BMD, and 3) determine the risk factors for lower BMD in COPD patients. The Web of Science and PubMed databases were searched on September 25, 2023. Studies where BMD was evaluated with computed tomography (CT) or quantitative CT in patients with COPD were included in the review. We collected data on the number of COPD patients, the average age, average body mass index, average predicted forced expiratory volume in one second (%) or Global Initiative for Chronic Obstructive Lung Disease stage, the average of low attenuation areas, the use of corticosteroid therapy, the use of osteoporosis therapy, the average BMD, and the location of BMD measurement. Twelve studies met our review criteria. Although in several studies COPD was associated with a decreased BMD, most of the studies suggested that COPD, especially in its milder forms, was not strongly associated with osteopenia or osteoporosis of the thoracic and lumbar spine.
我们系统地回顾了当前的研究文献，以：1）研究慢性阻塞性肺疾病（COPD）患者与非 COPD 对照者之间的骨密度（BMD）是否存在差异；2）确定 COPD 的严重程度和亚型对 BMD 的影响；3）确定 COPD 患者 BMD 降低的危险因素。我们于 2023 年 9 月 25 日在 Web of Science 和 PubMed 数据库中进行了检索。本综述纳入了使用计算机断层扫描（CT）或定量 CT 评估 COPD 患者 BMD 的研究。我们收集了 COPD 患者数量、平均年龄、平均体重指数、平均预计 1 秒用力呼气量（%）或全球慢性阻塞性肺疾病倡议分期、低衰减区的平均值、皮质类固醇治疗的使用情况、骨质疏松症治疗的使用情况、平均 BMD 以及 BMD 测量部位的数据。有 12 项研究符合我们的综述标准。尽管在几项研究中 COPD 与 BMD 降低有关，但大多数研究表明，COPD 尤其是在其较轻的形式中，与胸腰椎的骨质疏松症或骨量减少并无强烈关联。
