Nguyen Minh Hien, Nguyen Thi Yen Nhi, Le Thien Han Nguyen, Le Thi Ngoc Tam, Chau Ngoc Trong Nghia, Le Tu Manh Huy, Huy Nguyen Bui Quoc
University of Health Sciences, Vietnam National University Ho Chi Minh City, YA1 Administrative Building, Hai Thuong Lan Ong Street, Dong Hoa Ward, Di An City, Binh Duong Province, Viet Nam.
Vietnam National University Ho Chi Minh City, Linh Trung Ward, Thu Duc City, Ho Chi Minh city, Viet Nam.
Heliyon. 2024 Oct 11;10(20):e39229. doi: 10.1016/j.heliyon.2024.e39229. eCollection 2024 Oct 30.
Despite extensive research in chemotherapy, global cancer concerns persist, exacerbated by the challenge of drug resistance, which imposes economic and medical burdens. Natural compounds, particularly secondary metabolites from medicinal plants, present promising avenues for overcoming cancer drug resistance due to their diverse structures and essential pharmacological effects. This review provides a comprehensive exploration of cancer cell resistance mechanisms and target actions for reversing resistance and highlights the and efficacy of noteworthy alkaloids, flavonoids, and other compounds, emphasizing their potential as therapeutic agents. The molecular properties supporting ligand interactions are thoroughly examined, providing a robust theoretical foundation. The review concludes by discussing methods including quantitative structure-activity relationships and molecular docking, offering insights into screening potential candidates. Current trends in clinical treatment, contributing to a holistic understanding of the multifaceted approaches to address cancer drug resistance are also outlined.
尽管在化疗方面进行了广泛研究，但全球癌症问题依然存在，耐药性这一挑战加剧了这些问题，给经济和医疗带来了负担。天然化合物，特别是药用植物的次生代谢产物，由于其多样的结构和重要的药理作用，为克服癌症耐药性提供了有前景的途径。本综述全面探讨了癌细胞耐药机制以及逆转耐药性的靶向作用，并强调了值得关注的生物碱、黄酮类化合物和其他化合物的疗效，突出了它们作为治疗剂的潜力。对支持配体相互作用的分子特性进行了深入研究，提供了坚实的理论基础。综述最后讨论了包括定量构效关系和分子对接在内的方法，为筛选潜在候选物提供了见解。还概述了临床治疗的当前趋势，有助于全面理解应对癌症耐药性的多方面方法。
