Yang Yuan, Lin Wu-Sheng, Wen Hui-Quan, Luo Xiao-Wen, Zhou Xiang, Zou Feng-Yun, Zhong Shuang-Shuang, Deng Ya-Yin, Shen Li-Shan, Zhang Yong, Li Qing-Ling, Guo Ruo-Mi
Department of Radiology, the Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China.
Department of Nuclear Medicine, the Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China.
Ther Adv Chronic Dis. 2024 Oct 24;15:20406223241293260. doi: 10.1177/20406223241293260. eCollection 2024.
Lumbar intervertebral disc and paravertebral muscle degeneration are common causes of chronic low back pain (CLBP). However, the exact etiology of CLBP in young patients remains unclear. Identifying the risk factors for CLBP in young patients could expedite the development of effective preventive recommendations.
To identify the factors influencing the presence and severity of CLBP in young patients by analyzing the associations between the fat content of the paravertebral muscles, T2 value of the lumbar intervertebral disc (LIVD), and visual analog scale (VAS) score.
Data for 23 patients diagnosed with CLBP were compared to those of 20 healthy young individuals.
The T2 values of the LIVD and fat content of the psoas major (PM), multifidus (MF), and erector spinae (ES) muscles for 23 young patients with CLBP and 20 healthy individuals were measured and compared using synthetic magnetic resonance imaging and proton density fat fraction analyses. Moreover, the factors (T2 values and fat content) associated with severe CLBP (assessed using the VAS score) were analyzed.
The fat content of the right MF and ES was higher in patients with CLBP than in healthy individuals ( < 0.05). The T2 values of each LIVD in the CLBP and control groups were not significantly different ( > 0.05). Moreover, the VAS scores did not correlate with the T2 values of the patients ( > 0.05). The fat content of the bilateral MF and ES muscles was positively associated with the VAS score in young patients with CLBP (left MF: = 0.506, = 0.01; right MF: = 0.532, = 0.01; left ES: = 0.636, < 0.01; and right ES: = 0.716, < 0.01).
Degeneration of the MF and ES may contribute to CLBP in young patients. In addition, the severity of CLBP is positively correlated with the degree of fat infiltration in the MF and ES.
腰椎间盘退变和椎旁肌退变是慢性下腰痛（CLBP）的常见原因。然而，年轻患者CLBP的确切病因仍不清楚。确定年轻患者CLBP的危险因素有助于加快制定有效的预防建议。
通过分析椎旁肌脂肪含量、腰椎间盘（LIVD）的T2值与视觉模拟评分（VAS）之间的关联，确定影响年轻患者CLBP发生及严重程度的因素。
将23例诊断为CLBP的患者的数据与20例健康年轻个体的数据进行比较。
采用合成磁共振成像和质子密度脂肪分数分析方法，测量并比较23例年轻CLBP患者和20例健康个体的LIVD的T2值以及腰大肌（PM）、多裂肌（MF）和竖脊肌（ES）的脂肪含量。此外，分析与严重CLBP（采用VAS评分评估）相关的因素（T2值和脂肪含量）。
CLBP患者右侧MF和ES的脂肪含量高于健康个体（<0.05）。CLBP组和对照组各LIVD的T2值无显著差异（>0.05）。此外，VAS评分与患者的T2值无相关性（>0.05）。CLBP年轻患者双侧MF和ES肌肉的脂肪含量与VAS评分呈正相关（左侧MF：=0.506，=0.01；右侧MF：=0.532，=0.01；左侧ES：=0.636，<0.01；右侧ES：=0.716，<0.01）。
MF和ES退变可能导致年轻患者CLBP。此外，CLBP的严重程度与MF和ES的脂肪浸润程度呈正相关。
