使用 mDIXON Quant 序列对阴茎脂肪浸润进行定量分析：与阴茎硬度和勃起功能障碍相关性的初步研究。
Quantification of penile fat infiltration using the mDIXON Quant sequence: a pilot study on the correlation with penis hardness and erectile dysfunction.
机构信息
Department of Radiology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Department of Urology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
出版信息
Br J Radiol. 2021 Jul 1;94(1123):20201400. doi: 10.1259/bjr.20201400. Epub 2021 Jun 16.
OBJECTIVE
The purpose of this study was to determine fat/water signal ratios using the mDIXON Quant sequence, quantitatively assess fat infiltration in the penis, and explore its possible relationship with penile hardness and erectile dysfunction.
METHODS
Routine pelvic MRI with the mDIXON Quant sequence was performed in 62 subjects, including 22 people in the normal group, 20 people in the normal erectile hardness group, and 20 people in the erectile dysfunction (ED) group. The fat/water signal ratio in the penis was measured using the mDIXON Quant sequence. Shear wave elastography was used to evaluate the hardness of the corpus cavernosa of the penis.
RESULTS
The fat/water signal ratio of the corpus spongiosum was significantly lower than that of the corpus cavernosa in the normal group ( = 0.03) and ED group ( < 0.01). There was no significant difference in the fat/water signal ratios between the normal group and the normal erectile hardness group. Fat infiltration was significantly lower, and erectile hardness was significantly higher in the normal erectile hardness group than in the ED group, and the fat infiltration in the left and right corpus cavernosa was inversely proportional to the erectile hardness of the penis.
CONCLUSION
This study suggests that mDIXON Quant can be used as a non-invasive, quantitative, and objective method for evaluating penile fat infiltration. This method could help diagnose penile fat infiltration in patients with erectile dysfunction and varying body mass indexes. Our results could also allow for a more accurate diagnosis and monitoring of erectile hardness function by quantitatively measuring penile fat infiltration.
ADVANCES IN KNOWLEDGE
(1) The proton density fat fraction technology is a new tool for the objective, quantitative and non-invasive evaluation of penile fat infiltration. (2) The quantitative measurement of fat infiltration in the corpora cavernosa might help diagnose and monitor penile erection hardness and its function more accurately.
目的
本研究旨在通过 mDIXON Quant 序列测定脂肪/水信号比值，定量评估阴茎脂肪浸润，并探讨其与阴茎硬度和勃起功能障碍的可能关系。
方法
对 62 例受试者行常规盆腔 MRI 及 mDIXON Quant 序列检查，包括正常组 22 例、正常勃起硬度组 20 例和勃起功能障碍（ED）组 20 例。采用 mDIXON Quant 序列测量阴茎的脂肪/水信号比值。应用剪切波弹性成像评估阴茎海绵体的硬度。
结果
正常组和 ED 组阴茎海绵体的脂肪/水信号比值均显著低于阴茎海绵体（ = 0.03 和 < 0.01）。正常组和正常勃起硬度组的脂肪/水信号比值无显著差异。正常勃起硬度组的脂肪浸润程度明显低于 ED 组，勃起硬度明显高于 ED 组，且左右侧阴茎海绵体的脂肪浸润程度与阴茎勃起硬度呈反比。
结论
mDIXON Quant 可作为一种非侵入性、定量、客观的方法，用于评估阴茎脂肪浸润。这种方法有助于诊断勃起功能障碍和不同体质量指数患者的阴茎脂肪浸润。通过定量测量阴茎脂肪浸润，我们的结果还可以更准确地诊断和监测阴茎勃起硬度功能。
知识进展
（1）质子密度脂肪分数技术是一种客观、定量、非侵入性评估阴茎脂肪浸润的新工具。（2）定量测量海绵体脂肪浸润可能有助于更准确地诊断和监测阴茎勃起硬度及其功能。
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