Chandramohan Deepak, Simhadri Prathap Kumar, Singh Prabhat, Gummadi Jyotsna, Valvani Rachna, Jena Nihar, Avula Sreekant
Nephrology, University of Alabama at Birmingham, Birmingham, USA.
Nephrology, AdventHealth, Daytona Beach, USA.
Cureus. 2024 Oct 4;16(10):e70863. doi: 10.7759/cureus.70863. eCollection 2024 Oct.
Diagnosing suspected renal or hepatic infections in autosomal dominant polycystic kidney disease (ADPKD) is difficult. Although 18-fluorodeoxyglucose positron-emission tomography-computed tomography (F-FDG PET-CT) is recommended to aid in the diagnosis, there is no consensus about its diagnostic accuracy. We aimed to investigate its diagnostic performance. To further assess this, we performed a meta-analysis. A comprehensive literature search screening of PubMed/MEDLINE, Embase, and Cochrane library databases through February 2024 was performed. Pooled sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and C-reactive protein (CRP) were estimated using the random effects model. Heterogeneity between studies was estimated using Cochran Q and I2 statistics. A total of seven studies were included in the final analysis. The pooled sensitivity of F-FDG PET-CT in diagnosing kidney and hepatic cyst infection was 82.6% (95% CI: 73.8-88.9; I2 16.9%), specificity was 77.6% (95% CI: 66.7-85.7; I2 15.6%), PPV was 79.4% (95% CI: 62.4-89.9; I2 62.6%), and NPV was 81.3% (95% CI: 72.7-87.7; I2 0%). The mean CRP was 244.2 mg/L (95% CI: 209.1-279.1; I2 66%). The results showed that F-FDG PET-CT demonstrated excellent pooled diagnostic performance in diagnosing renal and hepatic cyst infections in ADPKD.
诊断常染色体显性多囊肾病（ADPKD）中的疑似肾脏或肝脏感染很困难。尽管推荐使用18-氟脱氧葡萄糖正电子发射断层扫描-计算机断层扫描（F-FDG PET-CT）辅助诊断，但其诊断准确性尚无共识。我们旨在研究其诊断性能。为进一步评估，我们进行了一项荟萃分析。通过检索截至2024年2月的PubMed/MEDLINE、Embase和Cochrane图书馆数据库进行全面的文献筛选。使用随机效应模型估计合并敏感度、特异度、阳性预测值（PPV）、阴性预测值（NPV）和C反应蛋白（CRP）。使用Cochran Q和I²统计量估计研究间的异质性。最终分析共纳入7项研究。F-FDG PET-CT诊断肾囊肿和肝囊肿感染的合并敏感度为82.6%（95%CI：73.8-88.9；I² 16.9%），特异度为77.6%（95%CI：66.7-85.7；I² 15.6%），PPV为79.4%（95%CI：62.4-89.9；I² 62.6%），NPV为81.3%（95%CI：72.7-87.7；I² 0%）。平均CRP为244.2 mg/L（95%CI：209.1-279.1；I² 66%）。结果表明，F-FDG PET-CT在诊断ADPKD的肾囊肿和肝囊肿感染方面具有出色的合并诊断性能。
