Mussab Raja Muhammad, Khan Sharjeel, Bubak Saad Zulfiqar, Madni Abdulaziz, Ishaq Usman, Rimsha Shehzadi, Arqam Shehanshah Muhammed, Javed Hadia
Trauma and Orthopaedics, Jinnah Postgraduate Medical Centre, Karachi, PAK.
Trauma and Orthopaedics, Russells Hall Hospital, Dudley, GBR.
Cureus. 2024 Oct 4;16(10):e70821. doi: 10.7759/cureus.70821. eCollection 2024 Oct.
Introduction Infections pose a significant challenge in orthopedics related to implant failure. In orthopedic surgeries, surgical site infections (SSIs) extend the patient's hospital stay by an average of two weeks and also increase morbidity, double hospitalization rates, and triple the financial burden on the patient. This study aims to determine the common organism in patients with postoperative implant infections presenting at a tertiary care hospital. Methods A cross-sectional study was conducted in the Department of Orthopedic Surgery at JPMC Karachi over a six-month period, from November 24, 2022, to May 25, 2023. All patients of both genders aged 18-65 years presenting with postoperative implant infection within six hours of the development of symptoms were enrolled. Baseline demographic details and clinical histories were recorded at the time of presentation. A swab for culture and sensitivity was taken from the implant site using a sterile swab stick in patients with confirmed or suspected infections. Results Of 196 patients, the mean age of the patients was 48.47±5.19 years. Gender distribution showed that 49% of patients were females and 51% were males. The mean duration of surgery was 1.71±0.49 hours (100 minutes approximately); species 26% and 25.5% were the most common organisms isolated from infected surgical wounds, followed by Pseudomonas species in 32 patients (16.3%), species in 27 patients (13.8%), in 23 patients (11.7%), and coagulase-negative in 13 patients (6.6%). Conclusion In our cohort, species and species were the most common pathogens isolated from postoperative implant infections. The rise in species suggests that changes in prophylactic antibiotic practices may have contributed to this trend. Therefore, there is an urgent need to reassess current prophylactic strategies in light of the increasing incidence of infections caused by gram-negative bacteria.
感染在与植入物失败相关的骨科领域构成了重大挑战。在骨科手术中，手术部位感染（SSIs）使患者的住院时间平均延长两周，还会增加发病率、使住院率翻倍，并使患者的经济负担增加两倍。本研究旨在确定在一家三级护理医院就诊的术后植入物感染患者中的常见病原体。
于2022年11月24日至2023年5月25日的六个月期间，在卡拉奇JPMC的骨科进行了一项横断面研究。纳入所有年龄在18 - 65岁、症状出现后6小时内出现术后植入物感染的男女患者。就诊时记录基线人口统计学细节和临床病史。对于确诊或疑似感染的患者，使用无菌拭子从植入部位采集拭子进行培养和药敏试验。
196例患者中，患者的平均年龄为48.47±5.19岁。性别分布显示，49%的患者为女性，51%为男性。平均手术时长为1.71±0.49小时（约100分钟）；[此处原文species 26% and 25.5%表述有误，推测可能是两种细菌名称，暂不影响整体翻译]是从感染手术伤口分离出的最常见病原体，其次是假单胞菌属，有32例患者（16.3%），[此处原文species in 27 patients (13.8%)表述有误，推测可能是另一种细菌名称，暂不影响整体翻译]有27例患者（13.8%），[此处原文in 23 patients (11.7%)表述有误，推测可能是另一种细菌名称，暂不影响整体翻译]有23例患者（11.7%），凝固酶阴性[此处原文coagulase-negative in 13 patients (6.6%)表述有误，推测可能是另一种细菌名称，暂不影响整体翻译]有13例患者（6.6%）。
在我们的队列中，[此处原文species and species表述有误，推测可能是两种细菌名称，暂不影响整体翻译]是从术后植入物感染中分离出的最常见病原体。[此处原文species表述有误，推测可能是某种细菌名称，暂不影响整体翻译]的增加表明预防性抗生素使用方法的改变可能促成了这一趋势。因此，鉴于革兰氏阴性菌引起的感染发病率不断上升，迫切需要重新评估当前的预防策略。
