解读中枢神经系统-胶质瘤对话：对中枢神经系统-胶质瘤通信通路及其治疗潜力的深入洞察。
Deciphering the CNS-glioma dialogue: Advanced insights into CNS-glioma communication pathways and their therapeutic potential.
作者信息
Zhang Lu, Wang Yajing, Cai Xiaoxi, Mao Xinyuan, Sun Haitao
机构信息
Clinical Biobank Center, Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital and the Second Clinical Medical College, Southern Medical University, Guangzhou, China.
Neurosurgery Center, The National Key Clinical Specialty, The Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The Neurosurgery Institute of Guangdong Province, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
出版信息
J Cent Nerv Syst Dis. 2024 Oct 23;16:11795735241292188. doi: 10.1177/11795735241292188. eCollection 2024.
The field of cancer neuroscience has rapidly evolved, shedding light on the complex interplay between the nervous system and cancer, with a particular focus on the relationship between the central nervous system (CNS) and gliomas. Recent advancements have underscored the critical influence of CNS activity on glioma progression, emphasizing the roles of neurons and neuroglial cells in both the onset and evolution of gliomas. This review meticulously explores the primary communication pathways between the CNS and gliomas, encompassing neuro-glioma synapses, paracrine mechanisms, extracellular vesicles, tunneling nanotubes, and the integrative CNS-immune-glioma axis. It also evaluates current and emerging therapeutic interventions aimed at these pathways and proposes forward-looking perspectives for research in this domain.
癌症神经科学领域发展迅速，揭示了神经系统与癌症之间复杂的相互作用，尤其关注中枢神经系统（CNS）与胶质瘤之间的关系。最近的进展强调了中枢神经系统活动对胶质瘤进展的关键影响，突出了神经元和神经胶质细胞在胶质瘤发生和发展中的作用。本综述精心探讨了中枢神经系统与胶质瘤之间的主要通讯途径，包括神经胶质瘤突触、旁分泌机制、细胞外囊泡、隧道纳米管以及中枢神经系统-免疫-胶质瘤综合轴。它还评估了针对这些途径的现有和新兴治疗干预措施，并为该领域的研究提出了前瞻性观点。
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