Department of Blood Transfusion, Changzhou Hospital of Traditional Chinese Medicine, Changzhou, Jiangsu, China.
Department of Laboratory Medicine, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, China.
Front Immunol. 2024 Oct 18;15:1476030. doi: 10.3389/fimmu.2024.1476030. eCollection 2024.
The genesis and progression of tumors are multifaceted processes influenced by genetic mutations within the tumor cells and the dynamic interplay with their surrounding milieu, which incessantly impacts the course of cancer. The tumor microenvironment (TME) is a complex and dynamic entity that encompasses not only the tumor cells but also an array of non-cancerous cells, signaling molecules, and the extracellular matrix. This intricate network is crucial in tumor progression, metastasis, and response to treatments. The TME is populated by diverse cell types, including immune cells, fibroblasts, endothelial cells, alongside cytokines and growth factors, all of which play roles in either suppressing or fostering tumor growth. Grasping the nuances of the interactions within the TME is vital for the advancement of targeted cancer therapies. Consequently, a thorough understanding of the alterations of TME and the identification of upstream regulatory targets have emerged as a research priority. NF-κB transcription factors, central to inflammation and innate immunity, are increasingly recognized for their significant role in cancer onset and progression. This review emphasizes the crucial influence of the NF-κB signaling pathway within the TME, underscoring its roles in the development and advancement of cancer. By examining the interactions between NF-κB and various components of the TME, targeting the NF-κB pathway appears as a promising cancer treatment approach.
肿瘤的发生和发展是一个多方面的过程，受到肿瘤细胞内基因突变和与其周围环境动态相互作用的影响，这些因素不断影响着癌症的进程。肿瘤微环境（TME）是一个复杂而动态的实体，不仅包括肿瘤细胞，还包括一系列非癌细胞、信号分子和细胞外基质。这个错综复杂的网络在肿瘤进展、转移和对治疗的反应中起着至关重要的作用。TME 中存在着多种细胞类型，包括免疫细胞、成纤维细胞、内皮细胞，以及细胞因子和生长因子，它们在抑制或促进肿瘤生长方面都起着作用。深入了解 TME 内的相互作用对于推进靶向癌症治疗至关重要。因此，彻底了解 TME 的改变和识别上游调节靶点已成为研究的重点。NF-κB 转录因子是炎症和先天免疫的核心，它们在癌症的发生和发展中起着重要作用，这一点越来越受到人们的认识。本综述强调了 NF-κB 信号通路在 TME 中的关键影响，强调了它在癌症发展和进展中的作用。通过研究 NF-κB 与 TME 中各种成分的相互作用，靶向 NF-κB 途径似乎是一种很有前途的癌症治疗方法。
