Eto Fábio Hideki Nishi, Rodrigues Thiago Broggin Dutra, Matias Victor Elzio Gasperoni, Abdouni Yussef Ali
Irmandade Santa Casa de Misericórdia de São Paulo, Departamento de Ortopedia e Traumatologia "Pavilhao Fernandinho Simonsen", Grupo de Mão e Microcirurgia, Sao Paulo, SP, Brazil.
Irmandade Santa Casa de Misericordia de São Paulo, Departamento de Ortopedia e Traumatologia "Pavilhão Fernandinho Simonsen", Sao Paulo, SP, Brazil.
Acta Ortop Bras. 2024 Oct 28;32(5):e278892. doi: 10.1590/1413-785220243205e278892. eCollection 2024.
To evaluate the pregabalins adjuvant effect in patients with carpal tunnel syndrome (CTS) surgically treated, analyzing postoperative pain and the incidence of complex regional pain syndrome (CRPS).
Outpatient surgical candidates with CTS were selected and followed for 12 months, divided into three groups. The Control Group received a placebo, the Pregabalin 75 mg Group received a daily dose, and the Pregabalin 150 mg Group received a daily dose of the medication. Patient progress was evaluated using the visual analog scale (VAS) for pain and the DN4 neuropathic pain score before surgery, one month and three months after.
The administration of pregabalin to surgical patients with CTS did not demonstrate significant differences in immediate postoperative pain relief. Additionally, there were no statistically significant variations in the incidence of complications, such as CRPS, among the groups.
This study did not show a significant impact of pregabalin on postoperative pain relief or the reduction of CRPS incidence in patients undergoing surgery for CTS. These results suggest that pregabalin might not be an effective adjuvant in these surgical situations. .
评估普瑞巴林对接受手术治疗的腕管综合征(CTS)患者的辅助作用,分析术后疼痛及复杂性区域疼痛综合征(CRPS)的发生率。
选取门诊手术的CTS患者并随访12个月,分为三组。对照组接受安慰剂,普瑞巴林75mg组接受每日剂量的该药物,普瑞巴林150mg组接受每日剂量的该药物。在手术前、术后1个月和3个月,使用视觉模拟量表(VAS)评估疼痛以及DN4神经性疼痛评分来评估患者进展。
对接受手术的CTS患者给予普瑞巴林,在术后即刻疼痛缓解方面未显示出显著差异。此外,各组之间在CRPS等并发症发生率方面也没有统计学上的显著差异。
本研究未显示普瑞巴林对接受CTS手术患者的术后疼痛缓解或CRPS发生率降低有显著影响。这些结果表明,在这些手术情况下,普瑞巴林可能不是一种有效的辅助药物。