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海马体的形态学特征：厄瓜多尔的首个数据库。

Morphological characterization of the hippocampus: a first database in Ecuador.

作者信息

Cevallos Stefano Buitrón, Jerves Alex X, Vinueza Clayreth, Hernandez Dennis, Ávila Carlos, Auquilla Andrés, Alvear Óscar

机构信息

Fundación INSPIRE, INSπRE, Quito, Ecuador.

Unidad Académica de Informática, Ciencias de la Computación, e Innovación Tecnológica, Universidad Católica de Cuenca, Cuenca, Ecuador.

出版信息

Front Hum Neurosci. 2024 Oct 18;18:1387212. doi: 10.3389/fnhum.2024.1387212. eCollection 2024.

DOI:10.3389/fnhum.2024.1387212
PMID:39494388
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11528375/
Abstract

INTRODUCTION

The hippocampal volume is a well-known biomarker to detect and diagnose neurological, psychiatric, and psychological diseases. However, other morphological descriptors are not analyzed. Furthermore, not available databases, or studies, were found with information related to the hippocampal morphology from Latin-American patients living in the Andean highlands.

METHODS

The hippocampus is manually segmented by two medical imaging specialists on normal brain magnetic resonance images. Then, its morphological qualitative and quantitative descriptors (volume, sphericity, roundness, diameter, volume-surface ratio, and aspect ratio) are computed via 3D digital level-set-based mathematical representation. Furthermore, other morphological descriptors and their possible correlation with the hippocampal volume is analyzed.

RESULTS

We introduce a first database with the hippocampus' morphological characterization of 63 patients from Quito, Ecuador, male and female, aged between 18 and 95 years old.

DISCUSSION

This study provides new research opportunities to neurologists, psychologists, and psychiatrists, to further understand the hippocampal morphology of Andean and Latin American patients.

摘要

引言

海马体体积是检测和诊断神经、精神及心理疾病的一种广为人知的生物标志物。然而，尚未对其他形态学描述符进行分析。此外，未找到有关生活在安第斯高地的拉丁美洲患者海马体形态的可用数据库或研究。

方法

由两名医学影像专家在正常脑磁共振图像上手动分割海马体。然后，通过基于三维数字水平集的数学表示法计算其形态学定性和定量描述符（体积、球形度、圆度、直径、体积-表面积比和长宽比）。此外，还分析了其他形态学描述符及其与海马体体积的可能相关性。

结果

我们引入了第一个数据库，该数据库包含来自厄瓜多尔基多的63名患者（年龄在18至95岁之间，有男有女）的海马体形态特征。

讨论

本研究为神经学家、心理学家和精神科医生提供了新的研究机会，以进一步了解安第斯和拉丁美洲患者的海马体形态。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/619b/11528375/333edf14f6a4/fnhum-18-1387212-g012.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/619b/11528375/aa1f93eff22c/fnhum-18-1387212-g009.jpg
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