School of Nursing Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China.
Peking University First Hospital Beijing China.
J Am Heart Assoc. 2024 Nov 5;13(21):e036696. doi: 10.1161/JAHA.124.036696. Epub 2024 Nov 4.
This study aimed to examine whether baseline atherosclerosis was associated with subsequent short-term domain-specific cognitive decline.
This research was based on the BRAVE (Beijing Research on Aging and Vessel) study, a population-based prospective cohort study of adults aged 40 to 80 years, free of dementia. At baseline (wave 1, 2019), cognitive assessments and atherosclerosis measures, including carotid intima-media thickness, carotid plaques, coronary artery calcification, and brachial-ankle pulse wave velocity were conducted. Cognitive function was reassessed in wave 2 (2022-2023) using linear mixed models for analysis. A total of 932 participants (63.7% women; mean age, 60.0±6.9 years) were included. Compared with the lowest tertile of carotid intima-media thickness, carotid plaques, and brachial-ankle pulse wave velocity, or a coronary artery calcification score=0, the highest tertile of carotid intima-media thickness (β=-0.065 SD/y [95% CI, -0.112 to -0.017]; =0.008), carotid plaques (β=-0.070 SD/y [95% CI, -0.130 to -0.011]; =0.021), and brachial-ankle pulse wave velocity (β=-0.057 SD/y [95% CI, -0.105 to -0.010]; =0.018), and a coronary artery calcification score≥400 (β=-0.081 SD/y [95% CI, -0.153 to -0.008]; =0.029) were significantly associated with a faster decline in semantic fluency after multivariable adjustment. Moreover, greater carotid intima-media thickness, coronary artery calcification, and brachial-ankle pulse wave velocity were significantly associated with a faster decline in global cognition.
More significant atherosclerosis was associated with faster semantic fluency and global cognition declines.
本研究旨在探讨基线动脉粥样硬化是否与随后的短期特定领域认知能力下降有关。
本研究基于 BRAVE（北京老龄化与血管研究）研究，这是一项针对 40 至 80 岁成年人的基于人群的前瞻性队列研究，参与者无痴呆。在基线（第 1 波，2019 年）时进行认知评估和动脉粥样硬化测量，包括颈动脉内膜中层厚度、颈动脉斑块、冠状动脉钙化和肱踝脉搏波速度。在第 2 波（2022-2023 年）使用线性混合模型进行分析，重新评估认知功能。共纳入 932 名参与者（63.7%为女性；平均年龄 60.0±6.9 岁）。与颈动脉内膜中层厚度、颈动脉斑块和肱踝脉搏波速度最低三分位或冠状动脉钙化评分=0 相比，颈动脉内膜中层厚度最高三分位（β=-0.065 SD/y[95%CI，-0.112 至 -0.017]；=0.008）、颈动脉斑块（β=-0.070 SD/y[95%CI，-0.130 至 -0.011]；=0.021）和肱踝脉搏波速度（β=-0.057 SD/y[95%CI，-0.105 至 -0.010]；=0.018）以及冠状动脉钙化评分≥400（β=-0.081 SD/y[95%CI，-0.153 至 -0.008]；=0.029）与多变量调整后的语义流畅性下降速度更快显著相关。此外，颈动脉内膜中层厚度、冠状动脉钙化和肱踝脉搏波速度较大与整体认知能力下降速度较快显著相关。
动脉粥样硬化程度越严重，语义流畅性和整体认知能力下降速度越快。
