Department Speech-Language Pathology and Audiology, School of Health Care Sciences, Sefako Makgatho Health Sciences University, Pretoria.
S Afr J Commun Disord. 2024 Oct 9;71(1):e1-e6. doi: 10.4102/sajcd.v71i1.1014.
Hyperbilirubinaemia is a contributing condition to the prevalence of neonatal hearing loss. Because of its pathophysiology, the use of Otoacoustic Emissions (OAE) and Automated Auditory Brainstem Response (AABR) testing is essential in diagnosing hearing loss. Two-tier screening models are typically used in developing world contexts; however, a combined approach to testing (using both tests) should be used for early detection. Blood serum levels should also be monitored to determine how they impact audiological test results.
To determine the outcomes of using a combined testing approach of both OAE and Auditory Brainstem Response (ABR) for both screening and diagnostic testing of neonates with hyperbilirubinaemia and studying the relationship between the test results and the serum bilirubin levels.
A cross-sectional, comparative design was utilised. Forty neonates were tested (80 ears). Neonates underwent hearing screening and diagnostic testing (ABR and/or AABR and DPOAE tests). The study was conducted at a hospital in South Africa.
One-third (32.5%) of the neonates had comorbidities. Screening results indicated that the AABR test could identify more cases of abnormalities than DPOAEs (p = 0.001). Participants with a serum level greater than 10 mg/dL presented with abnormal diagnostic ABR test results while passing the DPOAE test (p 0.001).
Combined use of ABR and DPOAE testing yielded a greater identification of auditory pathology than using either test alone. Serum bilirubin levels can be used as an indicator for combination testing.Contribution: Combined use of ABR and DPOAE testing leads to greater identification of auditory pathology.
高胆红素血症是导致新生儿听力损失的常见原因。由于其病理生理学，使用耳声发射（OAE）和自动听性脑干反应（AABR）测试对于诊断听力损失至关重要。在发展中国家的背景下，通常使用两阶段筛查模型；然而，应该使用联合测试方法（同时使用两种测试）进行早期检测。还应监测血清胆红素水平，以确定其如何影响听力测试结果。
确定联合使用 OAE 和听觉脑干反应（ABR）对高胆红素血症新生儿进行筛查和诊断测试的结果，并研究测试结果与血清胆红素水平之间的关系。
采用了横断面、比较设计。对 40 名新生儿（80 只耳朵）进行了测试。新生儿接受了听力筛查和诊断测试（ABR 和/或 AABR 和 DPOAE 测试）。该研究在南非的一家医院进行。
三分之一（32.5%）的新生儿有合并症。筛查结果表明，AABR 测试比 DPOAE 测试更能识别出更多的异常病例（p=0.001）。血清胆红素水平大于 10mg/dL 的参与者，其诊断性 ABR 测试结果异常，而 DPOAE 测试通过（p<0.001）。
联合使用 ABR 和 DPOAE 测试比单独使用任何一种测试都能更准确地识别听力病理学。血清胆红素水平可用作联合测试的指标。
联合使用 ABR 和 DPOAE 测试可更准确地识别听力病理学。
