NICU, Pediatric Department, Abou-Reesh Hospital, Cairo University, Egypt.
Audiology Unit, ENT Department, Kasr Al-Aini Hospital, Cairo University, Egypt.
Int J Pediatr Otorhinolaryngol. 2021 Mar;142:110591. doi: 10.1016/j.ijporl.2020.110591. Epub 2020 Dec 23.
Hyperbilirubinemia is toxic to the auditory pathways and to the central nervous system, leaving sequelae such as hearing loss and encephalopathy. The damage to the auditory system occurs primarily within the brainstem and cranial nerve VIII, and manifests clinically as auditory neuropathy spectrum disorder.
to establish the relationship that exists between hyperbilirubinemia at birth as a risk factor of neonatal hearing loss in children born in ABOU-EL-REISH hospital.
we carried out of 60 neonates categorized into two groups: Group (A n = 30), neonates with hyperbilirubinemia; Group (B n = 30), neonates without hyperbilirubinemia.
Ten neonates were boys and twenty were girls from group A and eleven boys and nigh-teen girls from group B.There was significant statistical difference between group A and group B regarding ABR (P-value = 0.001) and a statistical difference regarding OAE (P-value = 0.103 in the right ear and 0.028 in the left ear). Also, our study shows the area under the curve and the diagnostic accuracy of total serum bilirubin (TSB) level for detection of hearing screening results (ABR) at a cut-off point 21 mg/dl (P-value = 0.008 and 0.009 in the right and left ears respectively.) CONCLUSIONS: Our study showed a relevant association between bilirubin levels and abnormal hearing screening results and the importance of combined screening with OAE and ABR tests.
高胆红素血症可对听觉通路和中枢神经系统造成毒害，导致听力损失和脑病等后遗症。听觉系统的损伤主要发生在脑干和第八颅神经内，临床上表现为听觉神经病谱系障碍。
确定 ABOU-EL-REISH 医院出生的新生儿高胆红素血症作为新生儿听力损失的危险因素之间的关系。
我们对 60 名新生儿进行了分类，分为两组：A 组（n=30），高胆红素血症新生儿；B 组（n=30），无高胆红素血症新生儿。
A 组有 10 名男婴和 20 名女婴，B 组有 11 名男婴和 19 名女婴。A 组和 B 组之间在 ABR 方面存在显著的统计学差异（P 值=0.001），而在 OAE 方面也存在统计学差异（右耳 P 值=0.103，左耳 P 值=0.028）。此外，我们的研究表明，总胆红素（TSB）水平的曲线下面积和诊断准确性可用于检测听力筛查结果（ABR），截断值为 21mg/dl（右耳和左耳的 P 值分别为 0.008 和 0.009）。
我们的研究表明胆红素水平与异常听力筛查结果之间存在相关性，联合 OAE 和 ABR 测试进行筛查非常重要。
