Penfold P L, Killingsworth M C, Sarks S H
Invest Ophthalmol Vis Sci. 1986 Mar;27(3):364-71.
Senile macular degeneration (SMD) is a leading cause of registered blindness in the United States and other Western countries. Loss of central vision develops as a result of atrophy of the retinal pigment epithelium or subretinal neovascularisation. The histopathology of the atrophic form of SMD has not been extensively studied. This paper illustrates at the light and electron microscope level the involvement the atrophic form of SMD. Additional features including pigment clumping and detachment of the retinal pigment epithelium at the advancing edge of the lesion are illustrated. Giant cells and MPS cells are typical features of granulomatous inflammation, and results suggest that they may play a role in the pathogenesis of SMD.
老年性黄斑变性（SMD）是美国和其他西方国家登记失明的主要原因。由于视网膜色素上皮萎缩或视网膜下新生血管形成，导致中心视力丧失。萎缩型SMD的组织病理学尚未得到广泛研究。本文在光学显微镜和电子显微镜水平上阐述了萎缩型SMD的病变情况。还展示了其他特征，包括病变前沿的色素聚集和视网膜色素上皮脱离。巨细胞和巨噬细胞是肉芽肿性炎症的典型特征，研究结果表明它们可能在SMD的发病机制中起作用。
