Sun Shengxin, Wang Xia, Hu Nvdan, Fu Shiqi, Li Shengkun
State Key Laboratory of Green Pesticide, Center for R&D of Fine Chemicals of Guizhou University, Guiyang, 550025, China.
Nat Prod Rep. 2025 Jan 22;42(1):113-150. doi: 10.1039/d4np00025k.
Covering: 1962 to 2023Drimane (hydro)quinones biosynthetically arise from the combination of drimane-type terpenoids with phenols or equivalents. Since the isolation of siccanin in 1962 (structure identified in 1967), over 200 natural drimane (hydro)quinones have been reported. They are widespread with remarkably diverse architectures and biological functions, which are achieved by varying either the drimane subunit, hydroquinone segment, or the fusion types of drimane and hydroquinone segment both of them. This type of natural products has drawn increasing attention in the discovery of novel pharmaceutical leads. Enormous efforts have been devoted to developing efficient and divergent synthesis approaches to facilitate the SAR study of drimane (hydro)quinones, aiming for more promising functional leads. This review is arranged mainly in terms of scaffold types of drimane (hydro)quinones and further categorized on the basis of biological functions. The mechanisms of action are also briefly discussed. Synthetic methods are categorized according to the strategies forging the Csp-Csp linker between drimane segments and (hydro)quinone subunits.
1962年至2023年
杜松烷（氢）醌通过杜松烷型萜类化合物与酚类或类似物的结合生物合成产生。自1962年分离出西卡宁（1967年确定其结构）以来，已报道了200多种天然杜松烷（氢）醌。它们分布广泛，具有极为多样的结构和生物学功能，这些功能通过改变杜松烷亚基、对苯二酚片段或者杜松烷和对苯二酚片段二者的融合类型来实现。这类天然产物在新型药物先导物的发现中受到越来越多的关注。人们付出了巨大努力来开发高效且多样的合成方法，以促进对杜松烷（氢）醌的构效关系研究，从而寻找更有前景的功能性先导物。本综述主要按照杜松烷（氢）醌的骨架类型进行编排，并根据生物学功能进一步分类。还简要讨论了其作用机制。合成方法根据在杜松烷片段和（氢）醌亚基之间构建Csp-Csp连接键的策略进行分类。
