Li Yibo, Liu Yuhao, Yin Tao, He Mi, Fang Changyun, Tang Xiong, Peng Shifang, Liu Yundong
Department of Orthodontics, Changsha Stomatological Hospital, Changsha, Hunan, 410004, P. R. China.
School of Stomatology, Hunan University of Chinese Medicine, Changsha, Hunan, 410208, P. R. China.
BMC Oral Health. 2025 May 13;25(1):713. doi: 10.1186/s12903-025-06078-z.
This study was to investigate associations of periodontitis, tooth loss and self-rated oral health with circadian syndrome.
Data regarding periodontitis, dentition, oral health questionnaire and circadian syndrome of 30-85 years old participants from US National Health and Nutrition Examination Survey 2005-2020 were analyzed. Periodontitis questions for periodontitis and dentition status were validated. Weighted multivariable logistic regression analyses were used.
Weighted prevalence of circadian syndrome and stage II-IV periodontitis was 33.29% and 88.87%, respectively. When compared with stage I periodontitis, stage II periodontitis was significantly associated with greater circadian syndrome prevalence after adjustment (odds ratio (OR) and 95% confidence interval (CI): Stage II: 1.35 (1.03, 1.76), P = 0.032; Stage III: 1.30 (0.97, 1.73), P = 0.069; Stage IV: 1.17 (0.82, 1.65), P = 0300). Stage II periodontitis was significantly associated with greater prevalence of lower high-density lipoprotein cholesterol (HDL) and elevated triglycerides and stage III and stage IV periodontitis were significantly associated with greater hypertension prevalence. A 1 tooth increase in the number of missing teeth was associated with a 1% increase in circadian syndrome and its components of obesity, elevated fasting plasma glucose (FPG) and short sleep. Poor or fair self-rated oral health showed a specificity of > 70% for periodontitis and lack of functional dentition. Meanwhile, poor or fair self-rated oral health had relatively higher levels of sensitivity for stage II-IV periodontitis (35%), stage III-IV periodontitis (46%), stage IV periodontitis (60%) and lacking functional dentition (56%). When compared to excellent self-rated oral health, good, fair and poor self-rated oral health were significantly associated with higher circadian syndrome prevalence (OR and 95% CI: Very good: 1.13 (0.97, 1.32), P = 0.120; Good: 1.34 (1.14, 1.57), P < 0.001; Fair: 1.41 (1.16, 1.71), P = 0.001; Poor: 1.63 (1.32, 2.03), P < 0.001). Additionally, participants with worse self-rated oral health had significantly higher prevalence of elevated FPG, hypertension, low HDL, elevated triglycerides, short sleep and depression.
Periodontitis, tooth loss and worse self-rated oral health were associated with circadian syndrome in US adults. Self-rated oral health may be a simple question to indicate oral and systemic health.
本研究旨在调查牙周炎、牙齿缺失和自我评估的口腔健康与昼夜节律综合征之间的关联。
分析了2005 - 2020年美国国家健康与营养检查调查中30 - 85岁参与者的牙周炎、牙列、口腔健康问卷和昼夜节律综合征数据。牙周炎问题和牙列状况经过验证。采用加权多变量逻辑回归分析。
昼夜节律综合征和II - IV期牙周炎的加权患病率分别为33.29%和88.87%。与I期牙周炎相比，调整后II期牙周炎与更高的昼夜节律综合征患病率显著相关（比值比（OR）和95%置信区间（CI）：II期：1.35（1.03，1.76），P = 0.032；III期：1.30（0.97，1.73），P = 0.069；IV期：1.17（0.82，1.65），P = 0.300）。II期牙周炎与较低的高密度脂蛋白胆固醇（HDL）升高和甘油三酯升高显著相关，III期和IV期牙周炎与更高的高血压患病率显著相关。缺牙数量每增加1颗，昼夜节律综合征及其肥胖、空腹血糖（FPG）升高和睡眠不足等组成部分的患病率增加1%。自我评估的口腔健康状况为差或一般对牙周炎和牙列功能缺失的特异性>70%。同时，自我评估的口腔健康状况为差或一般对II - IV期牙周炎（35%）、III - IV期牙周炎（46%）、IV期牙周炎（60%）和牙列功能缺失（56%）具有相对较高的敏感性。与自我评估的口腔健康状况为优秀相比，良好、一般和差的自我评估的口腔健康状况与更高的昼夜节律综合征患病率显著相关（OR和95% CI：非常好：1.13（0.97，1.32），P = 0.120；良好：1.34（1.14，1.57），P < 0.001；一般：1.41（1.16，1.71），P = 0.001；差：1.63（1.32，2.03），P < 0.001）。此外，自我评估的口腔健康状况较差的参与者FPG升高、高血压、HDL低、甘油三酯升高、睡眠不足和抑郁的患病率显著更高。
在美国成年人中，牙周炎、牙齿缺失和自我评估的口腔健康状况较差与昼夜节律综合征相关。自我评估的口腔健康状况可能是一个表明口腔和全身健康的简单问题。
