Cai Jingyi, Deng Yudi, Min Ziyang, Li Chaoyuan, Zhao Zhihe, Yi Jianru, Jing Dian
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Department of Implantology, School and Hospital of Stomatology, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Tongji University, Shanghai, China.
Stem Cell Rev Rep. 2025 Feb;21(2):291-303. doi: 10.1007/s12015-024-10807-2. Epub 2024 Nov 4.
Histone acetylation orchestrates a complex symphony of gene expression that controls cellular fate and activities, including the intricate processes of bone remodeling. Despite its proven significance, a systematic illustration of this process has been lacking due to its complexity, impeding clinical application. In this review, we delve into the central regulators of histone acetylation, unveiling their multifaceted roles in modulating bone physiology. We explore both contradictory and overlapping roles among these regulators and assess their potential as therapeutic targets for various bone disorders. Furthermore, we highlight current applications and discuss looming questions for a more effective use of epigenetic therapy in bone diseases, aiming to address gaps in knowledge and clinical practice. By providing a panoramic view of histone acetylation's impact on bone health and disease, this review unveils promising avenues for therapeutic intervention and enhances our understanding of skeletal physiology, crucial for improving therapeutical outcomes and quality of patients' life.
组蛋白乙酰化协调着基因表达的复杂交响曲，控制着细胞命运和活动，包括骨重塑的复杂过程。尽管其重要性已得到证实，但由于该过程的复杂性，一直缺乏对其系统的阐述，这阻碍了临床应用。在本综述中，我们深入研究组蛋白乙酰化的核心调节因子，揭示它们在调节骨生理中的多方面作用。我们探讨了这些调节因子之间相互矛盾和重叠的作用，并评估了它们作为各种骨疾病治疗靶点的潜力。此外，我们强调了当前的应用，并讨论了在骨疾病中更有效利用表观遗传疗法的紧迫问题，旨在填补知识和临床实践方面的空白。通过全景展示组蛋白乙酰化对骨骼健康和疾病的影响，本综述揭示了有前景的治疗干预途径，并加深了我们对骨骼生理学的理解，这对于改善治疗效果和患者生活质量至关重要。
