Affiliated Hospital of Shandong Second Medical University, School of Clinical Medicine, Weifang, China.
Medicine (Baltimore). 2024 Nov 1;103(44):e40273. doi: 10.1097/MD.0000000000040273.
Metabolic reprogramming is one of the characteristics of tumor cell metabolism. In tumor cells, there are multiple metabolic enzymes and membrane proteins to regulate metabolic reprogramming, and hypoxia inducible factor-1α (HIF-1α) can be regulated in transcription, translation, posttranslational modification and other aspects through multiple pathways, and HIF-1α affects multiple metabolic enzymes and membrane proteins during metabolic reprogramming, thus playing a central role in the metabolic reprogramming process, and thus has some implications for tumor therapy and understanding chemotherapy drug resistance. HIF-1α affects a number of metabolic enzymes and membrane proteins in the metabolic reprogramming process, thus playing a central role in the metabolic reprogramming process, which has certain significance for the treatment of tumors and the understanding of chemotherapeutic drug resistance. In this paper, we review the central role of HIF-1α in metabolic reprogramming, chemotherapeutic agents targeting HIF-1α, and chemotherapeutic drug resistance.
代谢重编程是肿瘤细胞代谢的特征之一。在肿瘤细胞中，存在多种代谢酶和膜蛋白来调节代谢重编程，缺氧诱导因子-1α（HIF-1α）可以通过多种途径在转录、翻译、翻译后修饰等方面进行调节，HIF-1α在代谢重编程过程中影响多种代谢酶和膜蛋白，因此在代谢重编程过程中起核心作用，从而对肿瘤治疗和理解化疗药物耐药性具有一定意义。HIF-1α 在代谢重编程过程中影响多种代谢酶和膜蛋白，因此在代谢重编程过程中起核心作用，这对肿瘤治疗和理解化疗药物耐药性具有一定意义。本文综述了 HIF-1α 在代谢重编程、针对 HIF-1α 的化疗药物以及化疗药物耐药性中的核心作用。
