Venkatesh Surya, Manaz P Mohammed, Priya M Harish, Ambiga G, Basu Soumyo
Department of Biotechnology, Sethu Institute of Technology, Virudhunagar, India.
Department of Biotechnology, Ayya Nadar Janaki Ammal College, Sivakasi, India.
Mol Biotechnol. 2024 Nov 4. doi: 10.1007/s12033-024-01312-5.
Short non-coding ribonucleic acids are also known as "Micro ribonucleic acids (miRNAs)". The miRNAs make a contribution to the regulation of genes and mitigation of cancer cell growth in humans. miRNAs play a significant role in several BPs, namely apoptosis, cell cycle progression, and development. It is well-recognized that miRNAs are crucial for the tumors' growth and also serve as Tumor Suppressors (TSs) or oncogenes. As miRNAs also act as an effective tumor suppressor, studying the molecular diversities of the miRNAs makes way to minimize cancer progression and the corresponding death rates in the future. Therefore, miRNAs along with their Biological Processes (BPs) and molecular diversities are thoroughly researched in this paper. Consequently, miRNAs particularly target their 3' UnTranslated Region (3'-UTR) for controlling the target mRNAs' stability and protein translation. So, this study also expresses the impact of microRNA variants in various cancer cells, namely Breast cancer, Gastric or stomach cancer, ovarian cancer, and lymphocytic leukemia. Furthermore, the database named PhenomiR and commercial kits that are used in the miRNA data analysis are discussed in this article to provide extensive knowledge about the molecular diversity analysis of miRNA and their influences on cancerous cells.
短链非编码核糖核酸也被称为“微小核糖核酸（miRNAs）”。miRNAs有助于人类基因调控和抑制癌细胞生长。miRNAs在几个生物学过程中发挥重要作用，即细胞凋亡、细胞周期进程和发育。众所周知，miRNAs对肿瘤生长至关重要，并且还可作为肿瘤抑制因子（TSs）或癌基因。由于miRNAs也作为一种有效的肿瘤抑制因子，研究miRNAs的分子多样性有助于未来最大限度地减少癌症进展和相应的死亡率。因此，本文对miRNAs及其生物学过程（BPs）和分子多样性进行了深入研究。因此，miRNAs特别靶向其3'非翻译区（3'-UTR）来控制靶标mRNA的稳定性和蛋白质翻译。所以，本研究还阐述了微小RNA变体在各种癌细胞中的影响，即乳腺癌、胃癌、卵巢癌和淋巴细胞白血病。此外，本文还讨论了用于miRNA数据分析的名为PhenomiR的数据库和商业试剂盒，以提供有关miRNA分子多样性分析及其对癌细胞影响的广泛知识。
