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通信:瑞典北部首次发生静脉血栓形成后的癌症发病率和死亡率

Correspondence: Cancer incidence and mortality after a first-ever venous thrombosis in northern Sweden.

作者信息

Tran Minh-Hoang, Truong-Nguyen Kim-Huong

机构信息

NTT Hi-Tech Institute, Nguyen Tat Thanh University, Ho Chi Minh City, Vietnam.

Department of Pharmacy, Nhan Dan Gia Dinh Hospital, Ho Chi Minh City, Vietnam.

出版信息

Thromb J. 2024 Nov 4;22(1):96. doi: 10.1186/s12959-024-00667-8.

Abstract

We congratulate Hägg et al. on their study investigating cancer incidence and mortality following first-ever venous thromboembolism (VTE), which provides valuable insights into VTE as a potential marker for underlying malignancies. However, we highlight concerns regarding healthy user bias, the unclear follow-up duration, and inconsistent adjustment in the statistical analysis. We also suggest the use of the Fine-Gray subdistribution hazard model to address competing risks, and the accurate reporting of sex-gender terminology. Lastly, we advise caution in concluding a high incidence of cancer following first-ever VTE without pre-VTE data for comparison and recommend acknowledging potential surveillance bias when interpreting the higher cancer detection rate within 6 months of VTE diagnosis.

摘要

我们祝贺哈格等人开展了关于首次静脉血栓栓塞(VTE)后癌症发病率和死亡率的研究,该研究为VTE作为潜在的潜在恶性肿瘤标志物提供了有价值的见解。然而,我们强调对健康用户偏差、随访时间不明确以及统计分析中调整不一致的担忧。我们还建议使用Fine-Gray亚分布风险模型来处理竞争风险,并准确报告性别术语。最后,我们建议在没有VTE前数据进行比较的情况下,谨慎得出首次VTE后癌症高发的结论,并建议在解释VTE诊断后6个月内较高的癌症检出率时承认潜在的监测偏差。

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