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RETRACTION: RETRACTION: High-Resolution Imaging of Human Cancer Proteins Using Microprocessor Materials.撤稿声明:使用微处理器材料对人类癌症蛋白质进行高分辨率成像。撤稿声明
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撤稿声明:使用微处理器材料对人类癌症蛋白质进行高分辨率成像。撤稿声明

RETRACTION: RETRACTION: High-Resolution Imaging of Human Cancer Proteins Using Microprocessor Materials.

作者信息

Solares M. J., Jonaid G. M., Luqiu W. Y., Berry S., Khadela J., Liang Y., Evans M. C., Pridham K. J., Dearnaley W. J., Sheng Z., Kelly D. F.

出版信息

Chembiochem. 2025 May 5;26(9):e202400798. doi: 10.1002/cbic.202400798. Epub 2024 Nov 4.

DOI:10.1002/cbic.202400798
PMID:39497285
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12049554/
Abstract

M. J. Solares, G. M. Jonaid, W. Y. Luqiu, S. Berry, J. Khadela, Y. Liang, M. C. Evans, K. J. Pridham, W. J. Dearnaley, Z. Sheng and D. F. Kelly, "High-Resolution Imaging of Human Cancer Proteins Using Microprocessor Materials," ChemBioChem, 23, no. 17 (2022), e202200310, https://doi.org/10.1002/cbic.202200310. The above article, published online on 5 July 2022 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Ruben Ragg; and Wiley-VCH GmbH. The retraction has been agreed following a thorough peer review process conducted by the author's institution, Penn State. The editors' own independent investigation confirmed that density map for the p53 dimer does not align well with the model for Figures 2B and S3 A. Furthermore, it was found that the coordinate and map files associated with the article available in the Protein Data Bank [PDB accession codes 8F2I (p53 monomer), 8F2H (p53 dimer)] and Electron Microscopy Data Bank [EMDB accession codes EMD28817 (p53 monomer), EMD28816 (p53 dimer)] exhibit poor alignment throughout. In addition, the authors did not provide original research data, maps and models in question, to justify the findings. The editors' own independent investigation confirmed that the conclusions of this manuscript are not sufficiently supported. Author D. F. Kelly responded to our notice of retraction, but did not state their agreement nor disagreement. Author G. M. Jonaid agrees with the retraction. All other authors did not respond to our notice regarding the retraction.

摘要

M. J. 索拉雷斯、G. M. 乔奈德、W. Y. 卢丘、S. 贝里、J. 卡德拉、Y. 梁、M. C. 埃文斯、K. J. 普里德姆、W. J. 迪尔纳利、Z. 盛和D. F. 凯利,“使用微处理器材料对人类癌症蛋白质进行高分辨率成像”,《化学生物化学》,23卷,第17期(2022年),e202200310,https://doi.org/10.1002/cbic.202200310。上述文章于2022年7月5日在威利在线图书馆(wileyonlinelibrary.com)在线发表,已根据期刊主编鲁本·拉格与威利 - 维克希股份有限公司的协议撤回。撤回是在作者所在机构宾夕法尼亚州立大学进行全面同行评审后达成一致的。编辑们自己的独立调查证实,p53二聚体的密度图与图2B和S3A的模型不太吻合。此外,发现蛋白质数据库[PDB登录代码8F2I(p53单体)、8F2H(p53二聚体)]和电子显微镜数据库[EMDB登录代码EMD28817(p53单体)、EMD28816(p53二聚体)]中与该文章相关的坐标和图谱文件在整体上显示出较差的一致性。此外,作者没有提供有问题的原始研究数据、图谱和模型来证明这些发现。编辑们自己的独立调查证实,该手稿的结论没有得到充分支持。作者D. F. 凯利回复了我们的撤稿通知,但未表明同意或不同意。作者G. M. 乔奈德同意撤稿。所有其他作者均未回复我们关于撤稿的通知。