Department of Anesthesiology, the Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan Province, P. R. China.
Department of Pediatric Surgery, the Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan Province, P. R. China.
J Alzheimers Dis. 2024 Nov;102(1):150-161. doi: 10.1177/13872877241283849. Epub 2024 Oct 17.
The aging global population is increasing the attention to cognitive decline in older individuals.
This study sought to examine the potential link between the neutrophil percentage-to-albumin ratio (NPAR) and cognitive function.
We analyzed data from the National Health and Nutrition Examination Survey 2011-2014 using multivariate logistic regression and smooth curve fitting, to investigate the correlation between NPAR and cognitive performance. Restricted cubic spline analysis assessed the linear relationship with high-risk cognitive dysfunction, while piecewise linear regression identified thresholds. Subgroup analyses confirmed the consistency and reliability of our findings.
Our study included data from 2759 individuals aged >60 years. NPAR showed a significant correlation with Consortium to Establish a Registry for Alzheimer's Disease (CERAD) word learning score, CERAD delayed recall score, total z-score and a high risk of cognitive dysfunction. Furthermore, there were statistically significant trends in the changes in CERAD word learning, digit symbol substitution test, and CERAD delayed recall scores as the NPAR quartile increased, these trends were inverted U-shaped. When the NPAR exceeded 14.57, there was a positive association with the likelihood of a high risk of cognitive impairment. The link between NPAR and cognitive performance was notably stronger in individuals with moderate body mass index and those aged 73-80 years.
A strong link was observed between the NPAR and cognitive function. NPAR may serve as a tool to identify individuals at increased risk of cognitive decline.
全球人口老龄化加剧了人们对老年人认知能力下降的关注。
本研究旨在探讨中性粒细胞百分比与白蛋白比值（NPAR）与认知功能之间的潜在联系。
我们使用多元逻辑回归和光滑曲线拟合分析了 2011-2014 年国家健康和营养调查的数据，以调查 NPAR 与认知表现之间的相关性。受限立方样条分析评估了与高危认知功能障碍的线性关系，而分段线性回归则确定了阈值。亚组分析证实了我们研究结果的一致性和可靠性。
我们的研究纳入了 2759 名年龄>60 岁的个体的数据。NPAR 与认知障碍诊断和评估联盟（CERAD）单词学习评分、CERAD 延迟回忆评分、总 z 评分和高危认知功能障碍显著相关。此外，随着 NPAR 四分位值的增加，CERAD 单词学习、数字符号替代测试和 CERAD 延迟回忆评分的变化趋势呈显著的统计学意义，这些趋势呈倒 U 型。当 NPAR 超过 14.57 时，与高危认知障碍的发生可能性呈正相关。NPAR 与认知表现之间的关联在体质指数适中的个体和 73-80 岁的个体中更为明显。
NPAR 与认知功能之间存在密切联系。NPAR 可能成为识别认知能力下降风险增加的个体的一种工具。
