Muscogliati Rodrigo, Palliyil Nigil, Chin Daniel Shou Chien, Deogaonkar Kedar, Daher Mohammad, Najjar Elie, Quraishi Nasir
Centre for Spinal Studies and Surgery, Queens Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, GBR.
Hull York Medical School, University of Hull, Hull-York Medical School, Hull, GBR.
Cureus. 2024 Oct 5;16(10):e70884. doi: 10.7759/cureus.70884. eCollection 2024 Oct.
Chondrosarcomas are malignant, cartilage-forming neoplasms. As these tumours are resistant to chemotherapy and radiotherapy, en-bloc excision of the tumour with wide margins is the only option that provides maximum disease-free survival and possible cure. We present two cases of primary chondrosarcoma of the thoracic spine treated by multilevel en-bloc excision through an all-posterior approach. Case 1 describes a 48-year-old female who presented with mid-back pain for six months. MRI revealed an expansile lesion between T9 and T11; a biopsy confirmed this to be chondrosarcoma. Following a posterior-only approach, the entire tumour mass with the overlying pleura, part of the T9-T11 vertebral body and the posterior elements, as well as the posteromedial part of the ninth, tenth, and eleventh ribs, were removed en bloc. Case 2 describes a 29-year-old male who presented with mid-back pain for five months. MRI revealed a lesion at T10, which was later confirmed on histopathological examination to be chondrosarcoma, affecting T9-T11. Using a posterior-only approach, the entire tumour mass, with part of T8-T11 was delivered en bloc. Both patients made an uneventful recovery, and there were no signs of disease at 24 months post-operatively. Despite being technically demanding, multilevel en-bloc tumour resection of the spine remains the mainstay in certain primary tumours, as it is potentially curative. Although the overall complication percentage following multilevel en-bloc resections was high, the local recurrence rate was significantly low. While most published articles recommend a posterior-only approach for limited disease, the cases in this report suggest that a posterior-only approach could also be viable for select cases of multilevel chondrosarcoma.
软骨肉瘤是一种恶性的、形成软骨的肿瘤。由于这些肿瘤对化疗和放疗具有抗性,因此采用广泛切缘的整块切除肿瘤是唯一能提供最大无病生存期并有可能治愈的选择。我们报告两例经全后路途径进行多级整块切除治疗的胸椎原发性软骨肉瘤病例。病例1为一名48岁女性,出现中背部疼痛6个月。磁共振成像(MRI)显示T9和T11之间有一个膨胀性病变;活检证实为软骨肉瘤。采用仅后路的方法,整块切除了整个肿瘤肿块及其上方的胸膜、部分T9 - T11椎体和后部结构,以及第九、十和十一肋骨的后内侧部分。病例2为一名29岁男性,出现中背部疼痛5个月。MRI显示T10有一个病变,组织病理学检查后来证实为软骨肉瘤,累及T9 - T11。采用仅后路的方法,整块切除了整个肿瘤肿块以及部分T8 - T11。两名患者均顺利康复,术后24个月无疾病迹象。尽管技术要求高,但脊柱多级整块肿瘤切除在某些原发性肿瘤中仍然是主要治疗方法,因为它具有潜在的治愈性。虽然多级整块切除后的总体并发症发生率较高,但局部复发率显著较低。虽然大多数已发表的文章推荐对于局限性疾病采用仅后路的方法,但本报告中的病例表明,仅后路的方法对于某些多级软骨肉瘤病例也是可行的。