一例混合性神经内分泌癌-腺泡腺癌：前列腺癌三联疗法的应用
A case of mixed neuroendocrine carcinoma-acinar adenocarcinoma: Utilization of triplet therapy for prostate cancer.
作者信息
Ikeda Junichi, Taniguchi Hisanori, Takayama Hiroki, Masuo Yuki, Nakamoto Takahiro, Uchida Katsunori, Kinoshita Hidefumi
机构信息
Department of Urology and Andrology Kansai Medical University Hirakata Osaka Japan.
Department of Pathology Kansai Medical University Hirakata Osaka Japan.
出版信息
IJU Case Rep. 2024 Sep 1;7(6):459-462. doi: 10.1002/iju5.12778. eCollection 2024 Nov.
INTRODUCTION
Neuroendocrine prostate cancer is an aggressive histological subtype of prostate cancer with a poor prognosis. Neuroendocrine prostate cancer is traditionally treated with cisplatin-based chemotherapy, similar to that used in treating small-cell lung cancer. However, the therapeutic effectiveness of chemotherapy for neuroendocrine prostate cancer has been limited. This case report describes a response to triplet therapy using darolutamide, androgen deprivation therapy, and docetaxel, which was administered in a patient with mixed neuroendocrine prostate cancer.
CASE PRESENTATION
A 77-year-old man was newly diagnosed with mixed neuroendocrine prostate cancer. Serum prostate-specific antigen, neuron-specific enolase, and progastrin-releasing peptide levels were 62.2, 40.6, and 60.6 pg/mL, respectively. Multiple lymph node metastases were identified on a computed tomography scan, and bone scintigraphy revealed multiple bone metastases. The clinical stage was determined to be cT3bN1M1b. Ultimately, tumor size and serum markers decreased with triplet therapy.
CONCLUSION
We demonstrated the first case in which triplet therapy had been effective in the treatment of neuroendocrine prostate cancer.
引言
神经内分泌前列腺癌是一种侵袭性的前列腺癌组织学亚型，预后较差。传统上，神经内分泌前列腺癌采用基于顺铂的化疗进行治疗，类似于治疗小细胞肺癌的化疗方法。然而，化疗对神经内分泌前列腺癌的治疗效果有限。本病例报告描述了一名混合性神经内分泌前列腺癌患者对使用达洛鲁胺、雄激素剥夺疗法和多西他赛的三联疗法的反应。
病例介绍
一名77岁男性新诊断为混合性神经内分泌前列腺癌。血清前列腺特异性抗原、神经元特异性烯醇化酶和胃泌素释放肽前体水平分别为62.2、40.6和60.6 pg/mL。计算机断层扫描发现多处淋巴结转移，骨闪烁显像显示多处骨转移。临床分期确定为cT3bN1M1b。最终，三联疗法使肿瘤大小和血清标志物降低。
结论
我们展示了首例三联疗法有效治疗神经内分泌前列腺癌的病例。
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