Lv Xiong, Xiang Chun, Zheng Yan, Zhou Wan-Xuan, Lv Xu-Ling
Department of Plastic Surgery, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, Zhejiang, People's Republic of China.
Clin Cosmet Investig Dermatol. 2024 Oct 31;17:2417-2426. doi: 10.2147/CCID.S492774. eCollection 2024.
Skin photoaging, resulting from prolonged exposure to ultraviolet (UV) radiation, is characterized by intricate biological changes involving oxidative damage and structural alterations. Despite an increasing demand for effective interventions, the current therapeutic options for treating skin photoaging are limited. We discovered through literature data search on PubMed that recent research has shifted its focus to the application of microneedle patches as an innovative approach to address this concern. Microneedle patches, serving as a novel transdermal delivery system, exhibit the potential to deliver bioactive substances such as cytokines, cellular vesicles, gene fragments and even alive algae to mitigate the effects of skin photoaging. This review aims to provide a comprehensive overview of recent advancements in research about utilizing microneedle patches for the treatment of skin photoaging and potential future directions in leveraging microneedle patches as clinical therapeutic agents for skin rejuvenation. Ultimately, we believe that microneedle patches have a broader application prospect in the fields of medical cosmetology and anti-photoaging.
皮肤光老化是由于长期暴露于紫外线（UV）辐射而引起的，其特征是涉及氧化损伤和结构改变的复杂生物学变化。尽管对有效干预措施的需求不断增加，但目前治疗皮肤光老化的选择有限。我们通过在PubMed上搜索文献数据发现，最近的研究已将重点转向应用微针贴片作为解决这一问题的创新方法。微针贴片作为一种新型的透皮给药系统，具有输送细胞因子、细胞囊泡、基因片段甚至活藻类等生物活性物质以减轻皮肤光老化影响的潜力。本综述旨在全面概述利用微针贴片治疗皮肤光老化的最新研究进展以及将微针贴片用作皮肤年轻化临床治疗剂的潜在未来方向。最终，我们相信微针贴片在医学美容和抗光老化领域具有更广阔的应用前景。
