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微针阵列技术在治疗性药物传递中的应用现状:从实验室到临床。

Current Status of Microneedle Array Technology for Therapeutic Delivery: From Bench to Clinic.

机构信息

Department of Biotechnology, School of Life Science and Biotechnology, Adamas University, Kolkata, West Bengal, 700126, India.

Department of Zoology, Fakir Mohan University, Vyasa Vihar, Balasore, Odisha, 756020, India.

出版信息

Mol Biotechnol. 2024 Dec;66(12):3415-3437. doi: 10.1007/s12033-023-00961-2. Epub 2023 Nov 21.

DOI:10.1007/s12033-023-00961-2
PMID:37987985
Abstract

In recent years, microneedle (MN) patches have emerged as an alternative technology for transdermal delivery of various drugs, therapeutics proteins, and vaccines. Therefore, there is an urgent need to understand the status of MN-based therapeutics. The article aims to illustrate the current status of microneedle array technology for therapeutic delivery through a comprehensive review. However, the PubMed search was performed to understand the MN's therapeutics delivery status. At the same time, the search shows the number no of publications on MN is increasing (63). The search was performed with the keywords "Coated microneedle," "Hollow microneedle," "Dissolvable microneedle," and "Hydrogel microneedle," which also shows increasing trend. Similarly, the article highlighted the application of different microneedle arrays for treating different diseases. The article also illustrated the current status of different phases of MN-based therapeutics clinical trials. It discusses the delivery of different therapeutic molecules, such as drug molecule delivery, using microneedle array technology. The approach mainly discusses the delivery of different therapeutic molecules. The leading pharmaceutical companies that produce the microneedle array for therapeutic purposes have also been discussed. Finally, we discussed the limitations and future prospects of this technology.

摘要

近年来,微针(MN)贴片作为一种替代技术,用于经皮输送各种药物、治疗蛋白和疫苗。因此,迫切需要了解基于 MN 的治疗方法的现状。本文旨在通过全面综述,说明用于治疗输送的微针阵列技术的现状。然而,通过 PubMed 搜索来了解 MN 的治疗输送现状。同时,搜索显示有关 MN 的出版物数量正在增加(63 篇)。搜索使用的关键字是“涂层微针”、“空心微针”、“可溶解微针”和“水凝胶微针”,这些关键字也呈上升趋势。同样,本文重点介绍了不同微针阵列在治疗不同疾病方面的应用。本文还说明了基于 MN 的治疗临床试验不同阶段的现状。它讨论了使用微针阵列技术输送不同的治疗分子,例如药物分子输送。该方法主要讨论了不同治疗分子的输送。用于治疗目的生产微针阵列的主要制药公司也已讨论。最后,我们讨论了该技术的局限性和未来前景。

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Industrial perspectives for personalized microneedles.个性化微针的产业前景。
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Vaccine-Induced Immunity Elicited by Microneedle Delivery of Influenza Ectodomain Matrix Protein 2 Virus-like Particle (M2e VLP)-Loaded PLGA Nanoparticles.流感包膜基质蛋白 2 病毒样颗粒(M2e VLP)负载 PLGA 纳米颗粒经微针递呈诱导的疫苗免疫原性。
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Microneedles: An Emerging Vaccine Delivery Tool and a Prospective Solution to the Challenges of SARS-CoV-2 Mass Vaccination.
无烧结低温处理3D纳米打印玻璃的几何决定因素
Microsyst Nanoeng. 2025 Jul 17;11(1):145. doi: 10.1038/s41378-025-00983-7.
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Applications and prospects of biomaterials in diabetes management.生物材料在糖尿病管理中的应用与前景
Front Bioeng Biotechnol. 2025 Mar 7;13:1547343. doi: 10.3389/fbioe.2025.1547343. eCollection 2025.
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What Is the Optimal Geometry of Dissolving Microneedle Arrays? A Literature Review.溶解微针阵列的最佳几何形状是什么?文献综述。
Pharmaceutics. 2025 Jan 17;17(1):124. doi: 10.3390/pharmaceutics17010124.
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Novel vaccine strategies to induce respiratory mucosal immunity: advances and implications.诱导呼吸道黏膜免疫的新型疫苗策略:进展与影响
MedComm (2020). 2025 Jan 16;6(2):e70056. doi: 10.1002/mco2.70056. eCollection 2025 Feb.
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Advancements and challenges in mRNA and ribonucleoprotein-based therapies: From delivery systems to clinical applications.基于mRNA和核糖核蛋白的疗法的进展与挑战:从递送系统到临床应用
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The Necessity to Investigate In Vivo Fate of Nanoparticle-Loaded Dissolving Microneedles.研究载纳米颗粒的溶解微针体内命运的必要性。
Pharmaceutics. 2024 Feb 17;16(2):286. doi: 10.3390/pharmaceutics16020286.
微针:一种新兴的疫苗递送工具以及应对新冠病毒大规模疫苗接种挑战的潜在解决方案。
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