Sahoo Tanmoy, Prasanna Dasari Vijaya, Sridhar B, Subba Reddy B V
Fluoro-Agrochemicals, CSIR-Indian Institute of Chemical Technology, Hyderabad, India.
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Org Biomol Chem. 2024 Dec 11;22(48):9408-9412. doi: 10.1039/d4ob01493f.
An efficient and operationally simple photochemical method has been demonstrated under transition metal-free, photocatalyst-free, and oxidant-free conditions. In recent times, diaryliodonium salts have become one of the most popular arylating sources under photoinduced conditions. Herein, we developed a visible light induced arylation of heterocycles using an EDA complex that is formed from 2,6-lutidine and diaryliodonium triflate. Under light irradiation, the EDA complex generates the aryl radical that undergoes addition with 2-oxo-2-chromene-3-carbonitriles an SET process. This method serves as an effective tool to access biologically active and pharmaceutically relevant coumarin scaffolds.
在无过渡金属、无光催化剂和无氧化剂的条件下，已证明了一种高效且操作简单的光化学方法。近年来，二芳基碘鎓盐已成为光诱导条件下最受欢迎的芳基化来源之一。在此，我们利用由2,6-二甲基吡啶和三氟甲磺酸二芳基碘鎓盐形成的电子给体-受体（EDA）配合物，开发了一种可见光诱导的杂环芳基化反应。在光照下，EDA配合物产生芳基自由基，该自由基与2-氧代-2-色烯-3-腈发生加成反应，这是一个单电子转移（SET）过程。该方法是获得具有生物活性和药学相关性的香豆素支架的有效工具。
