盐酸美吡拉敏、盐酸甲氧苄二胺、盐酸噻吩二胺及盐酸去敏灵在斯普拉格-道利大鼠中的致癌性。
Carcinogenicity of methapyrilene hydrochloride, mepyramine hydrochloride, thenyldiamine hydrochloride, and pyribenzamine hydrochloride in Sprague-Dawley rats.
作者信息
Habs M, Shubik P, Eisenbrand G
出版信息
J Cancer Res Clin Oncol. 1986;111(1):71-4. doi: 10.1007/BF00402780.
Abstract
Four histamine antagonists, methapyrilene, thenyldiamine, mepyramine and pyribenzamine were tested for carcinogenicity in rats by continuous application in drinking water. Only methapyrilene displayed significant carcinogenic effects, inducing liver tumors in a dose-related pattern. Analogues not containing a thiophene ring (mepyramine, pyribenzamine) did not exhibit neoplastic effects under the experimental conditions.
摘要
通过在饮用水中持续给药，对四种组胺拮抗剂——新安替根、乙二胺、甲氧苄二胺和苯吡胺进行了大鼠致癌性测试。只有新安替根表现出显著的致癌作用，以剂量相关的方式诱发肝肿瘤。在实验条件下，不含噻吩环的类似物（甲氧苄二胺、苯吡胺）未表现出肿瘤形成作用。
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本文引用的文献
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Liver tumors induced in rats by oral administration of the antihistaminic methapyrilene hydrochloride.通过口服抗组胺药盐酸美吡拉敏在大鼠中诱导产生的肝肿瘤。
Science. 1980 Aug 15;209(4458):817-9. doi: 10.1126/science.7403848.
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The effects of methapyrilene hydrochloride on hepatocarcinogenicity and pentobarbital-induced sleeping time in rats and mice.
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Inability of methapyrilene to induce sister chromatid exchanges in vitro and in vivo.美吡拉敏在体内外均无法诱导姐妹染色单体交换。
Cancer Res. 1982 Nov;42(11):4614-8.
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Nitrosation and mutagenicity of some amine drugs.某些胺类药物的亚硝化作用和致突变性。
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Guidelines for simple, sensitive significance tests for carcinogenic effects in long-term animal experiments.长期动物实验中致癌作用简单、灵敏显著性检验指南。
IARC Monogr Eval Carcinog Risk Chem Hum Suppl. 1980(2 Suppl):311-426.
6
Chronic toxicity tests of pyrilamine maleate and methapyrilene hydrochloride in F344 rats.
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7
Distribution of the liver carcinogen methapyrilene in Fischer rats and its interaction with macromolecules.肝脏致癌物甲吡咯烷在费希尔大鼠体内的分布及其与大分子的相互作用。
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8
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