El Ghalbzouri Tarik, El Bardouni Tarek, El Bakkali Jaafar, El Hajjaji Otman, Satti Hicham, Arectout Assia, Hadouachi Maryam, Yerru Randa
Radiation and Nuclear Systems Laboratory ERSN, Faculty of Sciences, University Abdelmalek Essaadi, Tetouan, Morocco.
Royal School of Military Health Service, Rabat, Morocco.
Phys Eng Sci Med. 2025 Mar;48(1):87-102. doi: 10.1007/s13246-024-01492-z. Epub 2024 Nov 5.
Positron emission tomography (PET) using F-FDG is a well-known modality for the diagnosis of various diseases in patients of different ages, sexes, and states of health, which implies that internal radiation dosimetry is highly desired for different phantom anatomies. In this study, we validate "DoseCalcs," a new Monte Carlo platform that combines personalized internal dosimetry calculations with Monte Carlo simulations. To achieve that, we used the specific absorbed fraction (SAF) calculated by DoseCalcs and those from ICRP publication 133 to estimate the absorbed dose per injected activity (AD/IA) and effective dose per injected activity (ED/IA) for F-FDG. The investigation focused on various voxelized phantoms representing different age groups, including adult male and female, and pediatric phantoms of various ages, from newborn to 15 years old. Using the DoseCalcs Monte Carlo platform, we have simulated the emission of F-FDG positrons based on the energy spectrum provided in ICRP publication 107. The results demonstrated the impact of anatomical differences and different organ/tissue compositions on radiation absorption, with significant variations in the AD/IA across different phantoms. Interestingly, organs/tissues near the emission source showed higher AD/IA, highlighting the anatomical dependence on the phantom. When our results were compared to established reference data, especially from ICRP128, most organs/tissues had good agreement. Still, some cases have shown differences. This shows how important it is to use accurate radionuclide data and biokinetic modeling in internal dosimetry calculations. Furthermore, we compared AD/IA and ED/IA values calculated in newborns by DoseCalcs with those derived from alternative codes, MCNP and EGSnrc. While the results generally exhibited consistency, subtle variations underscored the influence of biokinetics modeling choices and computational methodologies. Overall, this research contributes valuable insights into the precision of internal dosimetry calculations using "DoseCalcs-Gui" by providing one platform for Monte Carlo simulation and personalized internal dosimetry in nuclear medicine. The DoseCalcs platform is free for research and available for download at www.github.com/TarikEl/DoseCalcs-Gui .
使用F-FDG的正电子发射断层扫描（PET）是一种用于诊断不同年龄、性别和健康状况患者各种疾病的知名方法，这意味着不同的体模解剖结构非常需要进行内照射剂量测定。在本研究中，我们验证了 “DoseCalcs”，这是一个将个性化内照射剂量计算与蒙特卡罗模拟相结合的新蒙特卡罗平台。为实现这一目标，我们使用了DoseCalcs计算的特定吸收分数（SAF）以及ICRP第133号出版物中的特定吸收分数来估计F-FDG每注射活度的吸收剂量（AD/IA）和每注射活度的有效剂量（ED/IA）。研究集中在代表不同年龄组的各种体素化体模上，包括成年男性和女性，以及从新生儿到15岁不同年龄段的儿童体模。使用DoseCalcs蒙特卡罗平台，我们根据ICRP第107号出版物提供的能谱模拟了F-FDG正电子的发射。结果表明了解剖学差异和不同器官/组织组成对辐射吸收的影响，不同体模的AD/IA存在显著差异。有趣的是，发射源附近的器官/组织显示出较高的AD/IA，突出了对体模的解剖学依赖性。当我们将结果与既定的参考数据（尤其是来自ICRP128的数据）进行比较时，大多数器官/组织具有良好的一致性。不过，仍有一些情况存在差异。这表明在体内剂量计算中使用准确的放射性核素数据和生物动力学模型是多么重要。此外，我们将DoseCalcs在新生儿中计算的AD/IA和ED/IA值与从替代代码MCNP和EGSnrc得出的值进行了比较。虽然结果总体上表现出一致性，但细微的差异强调了生物动力学建模选择和计算方法的影响。总体而言，本研究通过提供一个用于核医学蒙特卡罗模拟和个性化内照射剂量测定的平台，为使用 “DoseCalcs-Gui” 进行内照射剂量计算的精度提供了有价值的见解。DoseCalcs平台可供研究免费使用，可在www.github.com/TarikEl/DoseCalcs-Gui下载。
