Wu Fang-Fang, Wang Jie, Liu Guo-Bin
Department of Peripheral Vascular Surgery, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Endocrinology Department of Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200071, China.
Chin J Integr Med. 2025 Jun;31(6):552-557. doi: 10.1007/s11655-024-3912-4. Epub 2024 Nov 5.
To investigate the clinical effects of thread-dragging therapy on gangrene of non-ischemic diabetic foot ulcers (NIDFU).
A total of 136 patients with NIDFU were recruited from the Department of Peripheral Vascular Surgery, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine between June 21, 2021 and February 1, 2023, and randomized into an intervention group and a control group, with 68 cases in each group. Both groups received basic treatment. The intervention group was treated with thread-dragging therapy, while the control group was treated with debridement combined with routine dressing changes after surgery. Both groups were treated continuously for 2 months. The amputation rates and changes in the ulcer area were compared between the groups. The inflammatory response index including peripheral white blood cells (WBCs), neutrophil percentage (NEUT%), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), procalcitonin (PCT), and interleukin 6 (IL-6) were compared between the two groups.
After treatment, the ulcer areas in the intervention group were significantly smaller than that of the control group (8.50±3.88 cm vs. 10.11±4.61 cm, P<0.05). The amputation rates of the two groups were not statistically significant (4.4% vs. 5.9%, P>0.05). Differences of WBCs count, CRP, and ESR before and after therapy in the intervention group were better than the control group (P<0.05). However, there were no significant differences in changes of NEUT%, PCT, and IL-6 between the two groups (P>0.05).
Thread-dragging therapy may be effective in the treatment of NIDFU, with the additional advantages of less tissue damage after healing. (Registration No. ChiCTR2100047496).
探讨拖线疗法治疗非缺血性糖尿病足溃疡（NIDFU）坏疽的临床疗效。
选取2021年6月21日至2023年2月1日上海中医药大学附属曙光医院周围血管外科收治的136例NIDFU患者，随机分为干预组和对照组，每组68例。两组均接受基础治疗。干预组采用拖线疗法，对照组采用清创术联合术后常规换药。两组均连续治疗2个月。比较两组的截肢率和溃疡面积变化。比较两组的炎症反应指标，包括外周血白细胞（WBC）、中性粒细胞百分比（NEUT%）、C反应蛋白（CRP）、红细胞沉降率（ESR）、降钙素原（PCT）和白细胞介素6（IL-6）。
治疗后，干预组溃疡面积明显小于对照组（8.50±3.88 cm vs. 10.11±4.61 cm，P<0.05）。两组截肢率差异无统计学意义（4.4% vs. 5.9%，P>0.05）。干预组治疗前后WBC计数、CRP和ESR的差异优于对照组（P<0.05）。然而，两组NEUT%、PCT和IL-6的变化差异无统计学意义（P>0.05）。
拖线疗法治疗NIDFU可能有效，愈合后组织损伤较小。（注册号：ChiCTR2100047496）
